Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Rabbit
IHC - Paraffin, Western blot, ELISA
Human STXBP1 / MUNC18-1
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Rabbit (tested or 100% immunogen sequence identity)
IHC - Paraffin (5 µg/ml)
Western blot (0.1 - 0.3 µg/ml)
Specificity and Use
STXBP1 / MUNC18-1 antibody was raised against synthetic peptide C-SRVSFEDQAPTME from the C-terminus of human STXBP1 (NP_003156.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Rabbit (100%); Opossum (92%); Platypus, Xenopus (85%).
STXBP1 Antibody, EIEE4 Antibody, HUNC18 Antibody, MUNC18-1 Antibody, N-Sec1 Antibody, NSEC1 Antibody, Protein unc-18 homolog 1 Antibody, Protein unc-18 homolog A Antibody, UNC18 Antibody, Unc18-1 Antibody, p67 Antibody, RBSEC1 Antibody, Unc-18A Antibody, Munc18 Antibody, Neuronal SEC1 Antibody, Syntaxin binding protein 1 Antibody, Syntaxin-binding protein 1 Antibody, UNC18A Antibody
May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.