STK4

serine/threonine kinase 4

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.

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Antibodies (43)

Proteins (6)

ELISA Kits (4)

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Custom (3)

Over-Expression Lysate (2)

Primary (43)

Recombinant (4)

Sandwich (1)

Target

STK4 (53)

Reactivity

Human (37)

Mouse (19)

Rat (4)

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Chicken (2)

Monkey (1)

Application

IHC (28)

IHC-P (7)

WB (38)

Flo (1)

ELISA (22)

ICC (2)

IF (2)

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rabbit (40)

mouse (3)

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IHCPlus (2)

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IgG (26)

IgG1,k (1)

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monoclonal mc (3)

polyclonal pc (40)

Clone

1D7-8A10 (1)

Format

96-Well Strip Plate (4)

AP Conjugated (1)

APC Conjugated (3)

Atto 390 Conjugated (1)

Atto 488 Conjugated (1)

Azide-free (2)

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aa385-415 (7)

aa443-470 (7)

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aa324-418 (1)

aa375-425 (1)

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STK4 Antibody (clone 1D7-8A10) LS-C133457

Antibody:

STK4 Mouse anti-Human Monoclonal (1D7-8A10) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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STK4 Antibody (aa324-418) LS-C186061

Antibody:

STK4 Rabbit anti-Human Polyclonal (aa324-418) Antibody

Reactivity:

Chicken, Bovine, Mouse, Rat, Human, Monkey

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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Human STK4 (Sandwich ELISA) ELISA Kit - LS-F66726

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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IHC-plus™ STK4 Antibody LS-B14911

(4.0) Rating

Antibody:

STK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ STK4 Antibody LS-B16551

(4.0) Rating

Antibody:

STK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$485

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STK4 Antibody LS-C489304

Antibody:

STK4 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

Flo, ICC, IF

Format:

Unconjugated

Price:

100 µl/$412

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STK4 Antibody LS-C755356

Antibody:

STK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

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Human STK4 Protein (Recombinant GST) (Full Length) - LS-G30576

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

30.03 kDa

Price:

10 µg/$479; 25 µg/$670

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STK4 Antibody (C-Terminus) LS-C287352

Antibody:

STK4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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STK4 Antibody LS-C406267

Antibody:

STK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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STK4 Antibody LS-C403027

Antibody:

STK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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STK4 Antibody (aa385-415) LS-C99493

Antibody:

STK4 Rabbit anti-Human Polyclonal (aa385-415) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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STK4 Antibody (aa385-415) LS-C323140

Antibody:

STK4 Rabbit anti-Human Polyclonal (aa385-415) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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STK4 Antibody (aa385-415, Biotin) LS-C223354

Antibody:

STK4 Rabbit anti-Human Polyclonal (aa385-415) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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STK4 Antibody (aa385-415, FITC) LS-C223356

Antibody:

STK4 Rabbit anti-Human Polyclonal (aa385-415) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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STK4 Antibody (aa385-415, APC) LS-C223353

Antibody:

STK4 Rabbit anti-Human Polyclonal (aa385-415) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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STK4 Antibody (aa385-415, Azide-free, HRP) LS-C223355

Antibody:

STK4 Rabbit anti-Human Polyclonal (aa385-415) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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STK4 Antibody (aa385-415, PE) LS-C223357

Antibody:

STK4 Rabbit anti-Human Polyclonal (aa385-415) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

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STK4 Antibody (p183) LS-C826863

Antibody:

STK4 Rabbit anti-Human Polyclonal (p183) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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STK4 Antibody (phospho-Thr183) LS-C826861

Antibody:

STK4 Rabbit anti-Human Polyclonal (pThr183) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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STK4 Antibody LS-C770954

Antibody:

STK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

60 µl/$343; 120 µl/$427; 200 µl/$559

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STK4 Antibody LS-C809736

Antibody:

STK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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STK4 Antibody (N-Terminus) LS-C16615

Antibody:

STK4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µl/$688

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STK4 Antibody (aa443-470) LS-C325464

Antibody:

STK4 Rabbit anti-Mouse Polyclonal (aa443-470) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

STK4 Antibody LS-C774931

Antibody:

STK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µg/$442

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