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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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STK11 / LKB1 Antibody (phospho‑Thr189) LS‑C16231
LKB1 antibody LS-C16231 is an unconjugated rabbit polyclonal antibody to human LKB1 (STK11). Validated for WB.
Antibody
Catalog
Size
Price
LS-C16231-100
100 µl
$575

Popular STK11 / LKB1 Products

Anti-STK11 / LKB1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B592 concentration 5 ug/ml.
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Anti-STK11 / LKB1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6669 dilution 1:50.
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Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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IHC of paraffin-embedded Human pancreas tissue using anti-STK11 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
Species: Human
Applications: IHC, IHC - Paraffin, Western blot
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using LKB1 Antibody. The picture on the right is blocked with the synthesized peptide.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Immunofluorescence, Peptide Enzyme-Linked Immunosorbent Assay

Product Description

LKB1 antibody LS-C16231 is an unconjugated rabbit polyclonal antibody to human LKB1 (STK11). Validated for WB.
About STK11 / LKB1
Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Q15831 NM_000455 NP_000446.1

STK11 Antibody, HLKB1 Antibody, Peutz-Jeghers syndrome Antibody, PJS Antibody, Serine/threonine kinase 11 Antibody, Liver kinase B1 Antibody, LKB1 Antibody


Specifications

Target
Human STK11 / LKB1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (1:1000)
Immunogen
STK11 / LKB1 antibody was raised against synthetic phosphopeptide (KLH coupled) corresponding to residues surrounding Thr189 of human LKB1.
Epitope
pThr189
Specificity
Detects overexpressed levels of LKB1 only when phosphorylated at threonine 189. Does not detect LKB1 phosphorylated at other sites.
Usage
Suitable for use in Western Blot. Western Blot: 1:1000.
Presentation
10 mM HEPES-Sodium, pH 7.5, 150 mM NaCl, 50% Glycerol, BSA
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: United States
Date Requested: 8/20/2018

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