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STAT2

signal transducer and activator of transcription 2, 113kDa

STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: signal transducer and activator of transcription 2, 113kDa
Synonyms: STAT2, ISGF-3, STAT113, p113
Target Sequences: NM_005419 NP_005410.1 P52630

Publications (2)

1
STAT2-dependent induction of RNA adenosine deaminase ADAR1 by type I interferon differs between mouse and human cells in the requirement for STAT1. George CX, Samuel CE. Virology. 2015 November;485:363-70. (Mouse) [Full Text Article] [PubMed:26335850] [PMC:PMC4619148]
2
The Transcription Factor T-bet Limits Amplification of Type I IFN Transcriptome and Circuitry in T Helper 1 Cells. Iwata S, Mikami Y, Sun HW, Brooks SR, Jankovic D, Hirahara K, Onodera A, Shih HY, Kawabe T, Jiang K, Nakayama T, Sher A, O'Shea JJ, Davis FP, Kanno Y. Immunity. 2017 June;46:983-991. (Mouse) [Full Text Article] [PubMed:28623086] [PMC:PMC5523825] Related Antibodies: LS-C10379.

☰ Filters
Antibodies (101)
ELISA Kits (19)
Proteins (7)
Cell-Based (1)
Cell-Based Phosphorylation (1)
Custom (3)
Development Kit (1)
DNA Binding (1)
Over-Expression Lysate (2)
Primary (101)
Recombinant (5)
Sandwich (12)
STAT2 (127)
Human (90)
Mouse (48)
Rat (35)
Chicken (1)
Dog (1)
Guinea pig (1)
Horse (1)
Monkey (6)
Pig (9)
Porcine (1)
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IHC (45)
IHC-P (11)
WB (90)
ELISA (40)
ICC (1)
IF (4)
IP (11)
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rabbit (97)
mouse (4)
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polyclonal pc (97)
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aa587-838 (8)
aa616-849 (8)
aa658-912 (8)
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aa600-626 (7)
aa820-851 (7)
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Leu684 (1)
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No (126)
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Human (4)
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STAT2 Rabbit anti-Mouse Polyclonal (pTyr689) Antibody
Mouse, Human
WB
Unconjugated
200 µl/$832
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STAT2 Rabbit anti-Human Polyclonal (aa801-851) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
STAT2 Antibody - Anti-STAT2 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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STAT2 Mouse anti-Mouse Monoclonal (Tyr690) (19G8.H2.H6) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
STAT2 Antibody - Immunofluorescence of monoclonal antibody to STAT2 on A-431 cell. [antibody concentration 10 ug/ml]
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STAT2 Mouse anti-Human Monoclonal (5G7) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
STAT2 Protein - Purified recombinant protein STAT2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
97.7 kDa
20 µg/$1,107
STAT2 Antibody - Anti-Stat2pY690 Antibody - Western Blot. Western blot of Immuno-chemicals affinity purified anti-Stat2pY690 antibody shows detection of Stat2pY690 protein (arrowhead) in Jurkat cells without (left lane) and with (right lane) 1000U/mL of IFN-a for 15 min at 37oC. Primary antibody was used at 1:1000. Personal Communication, A. Gamero, NCI, Bethesda, MD.
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STAT2 Rabbit anti-Human Polyclonal (pTyr690) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$567
STAT2 Antibody - Anti-STAT2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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STAT2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
STAT2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$798
STAT2 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
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STAT2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
STAT2 Antibody - Western blot of recombinant STAT2.
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STAT2 Rabbit anti-Human Polyclonal (aa616-849) Antibody
Pig, Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
STAT2 Antibody - 1:100 staining human breast carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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STAT2 Rabbit anti-Human Polyclonal (pTyr690) Antibody
Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
STAT2 Antibody - 1:100 staining human breast carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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STAT2 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
STAT2 Antibody - Immunohistochemistry of paraffin-embedded human lung cancer at dilution of 1:100
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STAT2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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STAT2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
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STAT2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$351
STAT2 Protein - Recombinant Signal Transducer And Activator Of Transcription 2 By SDS-PAGE
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E. coli
His-T7
30.7 kDa
10 µg/$277; 50 µg/$420; 100 µg/$670; 200 µg/$837; 1 mg/$1,928; 500 µg/$1,474; 5 mg/$2,927; 2 mg/$2,113
STAT2 Antibody - Anti-Stat2 monoclonal antibody was used at a 2.5 µg/mL to detect Stat2 in squamous epithelium from human skin (40X) showing moderate to strong nuclear and faint to moderate cytoplasmic staining (image). Expression of Stat2 is expected to be cytoplasmic, and nuclear upon activation. The image shows the localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain. Tissue was formalin-fixed and paraffin embedded.
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STAT2 Mouse anti-Mouse Monoclonal (Tyr690) (19G8.H2.H6) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
25 µl/$304
STAT2 Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using STAT2 (Phospho-Tyr690) Antibody. The picture on the right is blocked with the phospho peptide.
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STAT2 Rabbit anti-Human Polyclonal (pTyr690) Antibody
Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
STAT2 Rabbit anti-Human Polyclonal (aa820-851) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
STAT2 Rabbit anti-Human Polyclonal (aa186-215) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
STAT2 Antibody - Western blot of Phospho-Stat2 (Y690) antibody
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STAT2 Rabbit anti-Human Polyclonal (630-710 aa) Antibody
Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
STAT2 Antibody - Western blot of Stat2 antibody
Select
STAT2 Rabbit anti-Human Polyclonal (630-710 aa) Antibody
Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
STAT2 Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer using STAT2 Polyclonal Antibody at dilution of 1:60.
Select
STAT2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
STAT2 Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using STAT2 (Ab-690) antibody.
Select
STAT2 Rabbit anti-Human Polyclonal (p690) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
STAT2 Antibody - P-peptide - + Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using STAT2 (Phospho-Tyr690) antibody.
Select
STAT2 Rabbit anti-Human Polyclonal (pTyr690) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
Viewing 1-25 of 127 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).