STAT1

signal transducer and activator of transcription 1, 91kDa

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

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Products

Antibodies (174)

ELISA Kits (20)

Proteins (16)

Type

Cell-Based (1)

Cell-Based Phosphorylation (3)

Custom (3)

DNA Binding (1)

DNA Binding Phosphorylation (2)

Over-Expression Lysate (6)

Primary (174)

Recombinant (10)

Sandwich (10)

Target

STAT1 (210)

Reactivity

Human (167)

Mouse (103)

Rat (80)

Bat (7)

Bovine (18)

Chicken (5)

Chimpanzee (12)

Dog (23)

Gibbon (12)

Guinea pig (11)

Hamster (11)

Horse (18)

Monkey (25)

Orangutan (12)

Pig (28)

Porcine (1)

Rabbit (8)

Sheep (16)

Zebrafish (3)

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Application

IHC (69)

IHC-P (38)

WB (154)

Flo (2)

DB (2)

ELISA (42)

ICC (4)

IF (18)

IP (35)

Peptide-ELISA (7)

Host

rabbit (145)

mouse (29)

Product Group

IHCPlus (10)

Isotype

IgG (100)

IgG1 (13)

IgG1,k (2)

IgG2a (1)

IgG2a,k (2)

IgG2b (4)

Clonality

monoclonal mc (30)

polyclonal pc (143)

recombinant monoclonal rmc (1)

Clone

1141CT26.2.1 (1)

12E8 (1)

1A8 (1)

4H9 (2)

5H7 (1)

8H11 (1)

AT1FA (1)

OTI13B10 (2)

OTI15H3 (2)

OTI9B12 (2)

PSM1 (2)

SM1 (3)

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Format

12 x 8-Well Microstrips (4)

96-Well Microplate (4)

96-Well Strip Plate (12)

AF488 Conjugated (1)

APC (2)

APC Conjugated (5)

Azide-free (2)

Biotin Conjugated (13)

Carrier-free (4)

Concentrated (1)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (13)

HRP Conjugated (13)

Magnetic beads Conjugated (1)

PE Conjugated (5)

Sepharose Conjugated (1)

Unconjugated (118)

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Epitope

pSer727 (19)

C-Terminus (12)

pTyr701 (12)

aa343-602 (8)

aa432-680 (8)

aa717-745 (7)

N-Terminus (4)

aa151-200 (4)

aa154-203 (4)

aa258-307 (4)

aa259-308 (4)

670-750 aa (2)

Asym-Me2-Arg31 (2)

Internal (2)

640-720 aa (1)

Amino Acid: 721-733 (1)

Gly695 (1)

Leu177 (1)

Ser727 (1)

Tyr701 (1)

aa1-712 (1)

aa114-143 (1)

aa141-190 (1)

aa175-225 (1)

aa364-378 (1)

aa519-712 (1)

aa668-717 (1)

aa694-743 (1)

aa700-750 (1)

aa711-730 (1)

aa712-750 (1)

aa736-750 (1)

p701 (1)

p727 (1)

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Publications

No (210)

Sample Type

Adherent Cell Cultures (4)

Cell Lysates (4)

Nuclear Lysates (3)

Plasma (4)

Serum (4)

Tissue Homogenates (3)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (8)

Species

Human (12)

Mouse (1)

Source

293T Cells (3)

Baculovirus (1)

E. coli (5)

HEK 293 Cells (5)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (3)

Select

IHC-plus™ STAT1 Antibody LS-B591

(4.0) Rating

Antibody:

STAT1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

0.05 mg/$440

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IHC-plus™ STAT1 Antibody (clone SM1) LS-B1874

(4.0) Rating

Antibody:

STAT1 Mouse anti-Human Monoclonal (SM1) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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IHC-plus™ STAT1 Antibody (C-Terminus) LS-B13056

(4.0) Rating

Antibody:

STAT1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Chicken, Bovine, Mouse, Dog, Rat, Pig, Human, Monkey

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

STAT1 Antibody (N-Terminus) LS-B4583

Antibody:

STAT1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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STAT1 Antibody (N-Terminus, HRP) LS-C437765

Antibody:

STAT1 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Orangutan, Gibbon, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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STAT1 Antibody (N-Terminus, Biotin) LS-C437762

Antibody:

STAT1 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Orangutan, Gibbon, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin

• Unconjugated
• HRP
• Biotin

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STAT1 Antibody (phospho-Ser727) LS-C352894

Antibody:

STAT1 Rabbit anti-Human Polyclonal (pSer727) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$315

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STAT1 Antibody (phospho-Tyr701) LS-C10369

Antibody:

STAT1 Mouse anti-Mouse Monoclonal (pTyr701) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$890

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Human STAT1 (Sandwich ELISA) ELISA Kit - LS-F39604

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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Human STAT1 Protein (Recombinant His) - LS-G922

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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STAT1 Antibody (C-Terminus) LS-C413033

Antibody:

STAT1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Pig, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$341

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Mouse/Human/Rat STAT1 (DNA-Binding ELISA) ELISA Kit - LS-F803

Type:

DNA Binding

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$662

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STAT1 Antibody (phospho-Tyr701) LS-C10368

Antibody:

STAT1 Rabbit anti-Mouse Polyclonal (pTyr701) Antibody

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$801

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IHC-plus™ STAT1 Antibody (aa1-712, clone AT1FA) LS-B9663

(4.0) Rating

Antibody:

STAT1 Mouse anti-Human Monoclonal (aa1-712) (AT1FA) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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STAT1 Antibody (clone 4H9) LS-C114639

Antibody:

STAT1 Mouse anti-Human Monoclonal (4H9) Antibody

Reactivity:

Dog, Human, Monkey

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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STAT1 Antibody (clone OTI15H3) LS-C114663

Antibody:

STAT1 Mouse anti-Human Monoclonal (OTI15H3) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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STAT1 Antibody LS-C747274

Antibody:

STAT1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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STAT1 Antibody (C-Terminus) LS-C30470

Antibody:

STAT1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

IHC-plus™ STAT1 Antibody (Internal) LS-B13955

(4.0) Rating

Antibody:

STAT1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Bovine, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

Human STAT1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66963

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.9 kDa

Price:

20 µg/$1,107

Select

Mouse/Human/Rat Phospho-STAT1 (Tyr701) (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F924

Type:

DNA Binding Phosphorylation

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$735

Select

Mouse/Human/Rat Phospho-STAT1 (Ser727) (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F914

Type:

DNA Binding Phosphorylation

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$735

Select

STAT1 Antibody (clone 1A8) LS-C198276

Antibody:

STAT1 Mouse anti-Human Monoclonal (1A8) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

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STAT1 Antibody (Gly695) LS-C176216

Antibody:

STAT1 Rabbit anti-Human Polyclonal (Gly695) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

STAT1 Antibody (phospho-Ser727) LS-C178103

Antibody:

STAT1 Rabbit anti-Human Polyclonal (pSer727) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$328; 100 µl/$419

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