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STARD13 is a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene Name: | StAR-related Lipid Transfer (START) Domain Containing 13 |
Synonyms: | STARD13, 46H23.2, DLC-2, DLC2, GT650, LINC00464, Rho GTPase-activating protein, START domain containing 13, ARHGAP37 |
Target Sequences: | NM_178006 NP_821074.1 Q9Y3M8 |
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