Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
SSR1 Antibody, Signal sequence receptor Antibody, SSR-alpha Antibody, TRAP-alpha Antibody, TRAP alpha Antibody, Ssr Antibody, SSR alpha subunit Antibody, Trap-a Antibody, TRAPA Antibody
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human alpha-signal sequence receptor gene (SSR1), also referred to as TRAP alpha, maps to the short arm of chromosome 6. SSR1 has several mRNA species as a result of complex alternative polyadenylation.
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with SSR1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
SSR1 Antibody western blot of HeLa,mouse NIH-3T3 cell line lysates (35 ug/lane). The SSR1 antibody detected the SSR1 protein (arrow).
Western blot of SSR1 (arrow) using rabbit SSR1 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SSR1 gene (Lane 2) (Origene Technologies).