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SRF / Serum Response Factor

serum response factor (c-fos serum response element-binding transcription factor)

SRF / Serum Response Factor is a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: serum response factor (c-fos serum response element-binding transcription factor)
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: SRF, Serum response factor, MCM1
Target Sequences: NM_003131 NP_003122.1 P11831

Publications (1)

1
An Alternative Promoter in Intron1 of the Renin Gene is Regulated by Glucose Starvation via Serum Response Factor. Philipp Lutze, Heike Wanka, Inga Bäumgen, Doreen Staar, Bianka Grunow, Jörg Peters. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017 July;42:1447-1457. [Full Text Article] [PubMed:28715805]

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Antibodies (59)
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SRF / Serum Response Factor (75)
Human (63)
Mouse (46)
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SRF / Serum Response Factor Antibody - Anti-SRF antibody IHC of human prostate, fibromuscular stroma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (aa71-120) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
SRF / Serum Response Factor ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
SRF / Serum Response Factor Antibody - Anti-SRF / Serum Response Factor antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (aa41-90) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (100-180 aa) Antibody
Mouse, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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SRF / Serum Response Factor Rabbit anti-Human Monoclonal (11C1071) Antibody
Mouse, Rat, Pig, Human, Monkey
IP, WB
Unconjugated
20 µl/$483; 100 µl/$763
SRF / Serum Response Factor Antibody - 1:200 staining human Testis tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (pSer99) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$341
SRF / Serum Response Factor Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
53.6 kDa
100 µg/$570; 20 µg/$395; 1 mg/$1,973
SRF / Serum Response Factor ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
SRF / Serum Response Factor Antibody - Immunohistochemistry of paraffin-embedded human testis tissue at dilution of 1:100
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
SRF / Serum Response Factor Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using SRF (Phospho-Ser77) Antibody. The picture on the right is blocked with the phospho peptide.
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (pSer77) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (40-120 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (10-90 aa) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
SRF / Serum Response Factor Antibody - Western blot of SRF antibody
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (40-120 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
SRF / Serum Response Factor Antibody - P-peptide - + Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using SRF (Phospho-Ser99) antibody.
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (pSer99) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
SRF / Serum Response Factor Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using SRF (Ab-99) antibody.
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (p99) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
SRF / Serum Response Factor Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using SRF (Phospho-Ser77) antibody.
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (pSer77) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
SRF / Serum Response Factor Antibody - Detection of Human SRF by Immunohistochemistry. Samples: FFPE sections of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-SRF used at a dilution of 1:1000. Detection: DAB.
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (aa458-508) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
SRF / Serum Response Factor Antibody - Detection of Human SRF by Immunohistochemistry. Samples: FFPE sections of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-SRF Lot1 used at a dilution of 1:1000 (1 ug/ml) (left). Detection: DAB.
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (aa25-75) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
SRF / Serum Response Factor Antibody - Staining LOVO cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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SRF / Serum Response Factor Mouse anti-Human Monoclonal (aa406-508) Antibody
Mouse, Human
ICC, WB
Unconjugated
100 µg/$832
SRF / Serum Response Factor Antibody - Immunohistochemistry (IHC) analysis of p-SRF (S103) pAb in paraffin-embedded human lung cancer tissue.
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (pSer103) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$328; 100 µl/$419
SRF / Serum Response Factor Antibody - IHC of SRF (G93) pAb in paraffin-embedded human breast carcinoma tissue.
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (Gly93) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
SRF / Serum Response Factor Antibody - Immunohistochemical analysis of SRF staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
SRF / Serum Response Factor Antibody - Immunohistochemical analysis of SRF (pS103) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP-conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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SRF / Serum Response Factor Rabbit anti-Human Polyclonal (pSer103) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$315
Viewing 1-25 of 75 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).