Human SPN / CD43

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

MT1

Unconjugated

Purified

Unmodified

Human monocytes

Reactive with a 95-115 kD highly sialated glycoprotein. This antibody is used to identify B cell lines and myeloma cells. It may be used in the diagnosis of chronic lymphocytic leukemias (CLL), as an alternative to CD5. The antigen detected by this antibody is the only marker expressed on neoplasms of the very early precursor cells. In immunohistochemistry it reacts with T cells, macrophages, myeloid cells and B cells (weak). It is used for the typing of lymphomas in paraffin sections. CD43 may function as an adhesion molecule via interaction with CD54 although this has not been definitely established. It may also inhibit leucocyte interactions with other cells. The antigen is involved in the activation of T-cells, B cells, NK cells and monocytes. The membrane proximal portion of the cytoplasmic domain mediates an association with the cytoskeleton.

• IHC
• IHC - Paraffin
• IHC - Frozen
• Flow Cytometry

The antibody is suitable for flow cytometry for analysis of blood and bone marrow samples.

PBS

Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles. Store undiluted.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P16150 NCBI: NM_003123 NP_003114.1