Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Unlike the proliferative action of SPHK1, SPHK2 has been shown to possess anti-proliferative or pro-apoptotic action. SphK2 suppresses growth and enhances apoptosis, independent of activation of S1P receptors. Sequence analysis revealed that SphK2 contains a 9 amino acid motif similar to that present in Bcl2-homology domain 3 (BH3)- only proteins, a pro-apoptotic subgroup of the Bcl-2 family.