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SPHK / SPHK1
sphingosine kinase 1
SPHK / SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | sphingosine kinase 1 |
| Family/Subfamily: | Non-protein Kinase , Sphingosine |
| Synonyms: | SPHK1, SK1, Sphingosine kinase 1, SPHK, SK 1, SPK 1, Sphingosine kinase type 1, SPK |
| Target Sequences: | NM_021972 NP_068807.2 Q9NYA1 |
Publications (2)
1
Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions. Fischer I, Alliod C, Martinier N, Newcombe J, Brana C, Pouly S. PloS one. 2011 6:e23905.
[PubMed:21887342]
[PMC:PMC3161076]
Related Antibodies: LS-C100769.
2
Bone morphogenetic protein-2 enhances gonadotropin-independent follicular development via sphingosine kinase 1. Masami Ito, Osamu Yoshino, Yosuke Ono, Akemi Yamaki-Ushijima, Tomoko Tanaka, Tomoko Shima, Makoto Orisaka, Akira Iwase, Akitoshi Nakashima, Shigeru Saito. American journal of reproductive immunology (New York, N.Y. : 1989). 2021 May;85:e13374. [Full Text Article]
[PubMed:33175430]
Related Antibodies: LS-A3106.
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SPHK / SPHK1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
SPHK / SPHK1 Rabbit anti-Human Polyclonal (aa286-315) Antibody
Mouse, Rat, Primate, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$393
SPHK / SPHK1 Rabbit anti-Mouse Polyclonal (pSer225) Antibody
Mouse
WB
Unconjugated
100 µg/$623
SPHK / SPHK1 Goat anti-Human Polyclonal (aa176-189) Antibody
Mouse, Hamster, Human, Monkey
IP, Peptide-ELISA, WB
Unconjugated
100 µg/$503
SPHK / SPHK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Hamster, Human, Monkey
ICC, IHC, IHC-P, WB
Unconjugated
1 Each/$485
Fast Shipping
SPHK / SPHK1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
SPHK / SPHK1 Rabbit anti-Human Polyclonal (FITC) Antibody
Mouse, Human
Flo, WB
FITC Conjugated
1 Each/$457
SPHK / SPHK1 Mouse anti-Human Monoclonal (OTI1A6) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
SPHK / SPHK1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1A6) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SPHK / SPHK1 Rabbit anti-Human Polyclonal (aa313-343) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SPHK / SPHK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
SPHK / SPHK1 Rabbit anti-Human Polyclonal (aa59-89) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
SPHK / SPHK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
SPHK / SPHK1 Rabbit anti-Human Polyclonal Antibody
Human
IHC
Unconjugated
50 µg/$631
SPHK / SPHK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
Wheat Germ Extract
GST
67.98 kDa
10 µg/$479; 25 µg/$670
Fast Shipping
SPHK / SPHK1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
SPHK / SPHK1 Rabbit anti-Human Polyclonal (aa286-315) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
200 µl/$734
SPHK / SPHK1 Rabbit anti-Human Polyclonal (aa286-315) (HRP) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
HRP Conjugated
200 µl/$952
SPHK / SPHK1 Rabbit anti-Human Polyclonal (aa286-315) (Biotin) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
SPHK / SPHK1 Rabbit anti-Human Polyclonal (aa286-315) (APC) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
APC Conjugated
200 µl/$952
SPHK / SPHK1 Rabbit anti-Human Polyclonal (aa286-315) (PE) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
PE Conjugated
200 µl/$952
SPHK / SPHK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
SPHK / SPHK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SPHK / SPHK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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