SP1

Sp1 transcription factor

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.

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Products

Antibodies (77)

ELISA Kits (9)

Proteins (3)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Custom (3)

DNA Binding (1)

Primary (77)

Recombinant (3)

Sandwich (2)

Target

SP1 (89)

Reactivity

Human (77)

Mouse (54)

Rat (47)

Bat (5)

Bovine (14)

Chicken (5)

Chimpanzee (6)

Dog (8)

Gibbon (3)

Goat (11)

Guinea pig (9)

Hamster (7)

Horse (1)

Monkey (8)

Pig (15)

Rabbit (11)

Sheep (1)

Xenopus (3)

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Application

IHC (37)

IHC-P (12)

WB (74)

Flo (8)

ChIP-Seq (1)

ELISA (23)

ICC (10)

IF (30)

IP (4)

Peptide-ELISA (9)

Host

rabbit (70)

mouse (4)

goat (3)

Product Group

IHCPlus (5)

Isotype

IgG (47)

IgG1 (3)

IgG1,k (1)

Clonality

monoclonal mc (4)

polyclonal pc (73)

Clone

1326CT463.109.176 (1)

1A5 (1)

4C8 (1)

4H6 (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (3)

96-Well Strip Plate (5)

APC (1)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (6)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (2)

Unconjugated (53)

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Epitope

aa260-591 (8)

aa677-707 (7)

pThr453 (5)

aa347-396 (4)

aa385-433 (4)

aa501-550 (4)

aa550-599 (4)

pThr739 (4)

Internal (2)

aa750-C-term (2)

390-470 aa (1)

680-760 aa (1)

C-Terminus (1)

Glu336 (1)

Gly447 (1)

aa421-470 (1)

aa572-585 (1)

aa68-82 (1)

aa700-740 (1)

aa706-755 (1)

aa735-785 (1)

aa752-785 (1)

p453 (1)

p739 (1)

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Publications

No (88)

Yes (1)

Sample Type

Adherent Cell Cultures (3)

Cell Lysates (2)

Nuclear Lysates (1)

Plasma (1)

Serum (1)

Tissue Homogenates (2)

Tag

GST, N-terminus (1)

His, N-Terminal (1)

His-GST (1)

Species

Human (3)

Source

E. coli (2)

Wheat Germ Extract (1)

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IHC-plus™ SP1 Antibody (clone 1A5) LS-B6148

(5.0) Rating

(1) Publication(s)

Antibody:

SP1 Mouse anti-Human Monoclonal (1A5) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ SP1 Antibody (Internal) LS-B1647

(4.0) Rating

Antibody:

SP1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

SP1 Antibody (clone 4H6) LS-C133444

Antibody:

SP1 Mouse anti-Human Monoclonal (4H6) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

IHC-plus™ SP1 Antibody (clone 4C8) LS-B6149

(4.0) Rating

Antibody:

SP1 Mouse anti-Human Monoclonal (4C8) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

Select

SP1 Antibody (aa700-740) LS-C287062

Antibody:

SP1 Rabbit anti-Human Polyclonal (aa700-740) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

SP1 Antibody (phospho-Thr739) LS-C117476

Antibody:

SP1 Rabbit anti-Human Polyclonal (pThr739) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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IHC-plus™ SP1 Antibody (aa735-785) LS-B14621

(4.0) Rating

Antibody:

SP1 Goat anti-Human Polyclonal (aa735-785) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

SP1 Antibody (phospho-Thr453) LS-C416503

Antibody:

SP1 Rabbit anti-Human Polyclonal (pThr453) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

SP1 Antibody (aa706-755) LS-C118246

Antibody:

SP1 Rabbit anti-Human Polyclonal (aa706-755) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

SP1 Antibody (aa750-C-term) LS-C287063

Antibody:

SP1 Rabbit anti-Human Polyclonal (aa750-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

ChIP-Seq, IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

Human SP1 Protein (Recombinant GST, N-terminus) (aa89-198) - LS-G60181

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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IHC-plus™ SP1 Antibody (aa421-470) LS-B7624

(4.0) Rating

Antibody:

SP1 Rabbit anti-Human Polyclonal (aa421-470) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

SP1 Antibody (aa677-707) LS-C161407

Antibody:

SP1 Rabbit anti-Human Polyclonal (aa677-707) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

SP1 Antibody (aa677-707) LS-C325297

Antibody:

SP1 Rabbit anti-Human Polyclonal (aa677-707) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

SP1 Antibody (aa677-707, Biotin) LS-C270045

Antibody:

SP1 Rabbit anti-Human Polyclonal (aa677-707) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

SP1 Antibody (aa677-707, FITC) LS-C270047

Antibody:

SP1 Rabbit anti-Human Polyclonal (aa677-707) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

SP1 Antibody (aa677-707, APC) LS-C270044

Antibody:

SP1 Rabbit anti-Human Polyclonal (aa677-707) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

SP1 Antibody (aa677-707, Azide-free, HRP) LS-C270046

Antibody:

SP1 Rabbit anti-Human Polyclonal (aa677-707) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

SP1 Antibody (aa677-707, PE) LS-C270049

Antibody:

SP1 Rabbit anti-Human Polyclonal (aa677-707) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

SP1 Antibody (phospho-Thr453) LS-C358335

Antibody:

SP1 Rabbit anti-Human Polyclonal (pThr453) Antibody

Reactivity:

Chicken, Bovine, Mouse, Rat, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

Select

SP1 Antibody (phospho-Thr739) LS-C800982

Antibody:

SP1 Rabbit anti-Human Polyclonal (pThr739) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

SP1 Antibody (phospho-Thr453) LS-C800981

Antibody:

SP1 Rabbit anti-Human Polyclonal (pThr453) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

SP1 Antibody (p453) LS-C826842

Antibody:

SP1 Rabbit anti-Human Polyclonal (p453) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

SP1 Antibody (phospho-Thr453) LS-C821939

Antibody:

SP1 Rabbit anti-Human Polyclonal (pThr453) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

SP1 Antibody LS-C808623

Antibody:

SP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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