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SOX4

SRY (sex determining region Y)-box 4

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.

Gene Name: SRY (sex determining region Y)-box 4
Family/Subfamily: Transcription factor
Synonyms: SOX4, EVI16, SRY-related HMG-box gene 4, Transcription factor SOX-4
Target Sequences: NM_003107 NP_003098.1 Q06945

Publications (4)

1
SOX4 interacts with plakoglobin in a Wnt3a-dependent manner in prostate cancer cells. Lai YH, Cheng J, Cheng D, Feasel ME, Beste KD, Peng J, Nusrat A, Moreno CS. BMC cell biology. 2011 12:50. (WB; Human) [Full Text Article] [PubMed:22098624] [PMC:PMC3227594]
2
A crucial epithelial to mesenchymal transition regulator, Sox4/Ezh2 axis is closely related to the clinical outcome in pancreatic cancer patients. Hasegawa S, Nagano H, Konno M, Eguchi H, Tomokuni A, Tomimaru Y, Asaoka T, Wada H, Hama N, Kawamoto K, Marubashi S, Nishida N, Koseki J, Mori M, Doki Y, Ishii H. International journal of oncology. 2016 48:145-52. (WB; Human) [Full Text Article] [PubMed:26648239]
3
BRAF/EZH2 Signaling Represses miR-129-5p Inhibition of SOX4 Thereby Modulating BRAFi Resistance in Melanoma. Kathleen Gebhardt, Bayram Edemir, Elisabeth Groß, Linda Nemetschke, Stefanie Kewitz-Hempel, Rose K C Moritz, Cord Sunderkötter, Dennis Gerloff. Cancers. 2021 May;13: [Full Text Article] [PubMed:34063443] [PMC:PMC8155874] Related Antibodies: LS-C499849.
4
Hypoxia-sensitive long noncoding RNA CASC15 promotes lung tumorigenesis by regulating the SOX4/ß-catenin axis. Jianyong Sun , Yanlu Xiong, Kuo Jiang, Bo Xin, Tongtong Jiang, Renji Wei, Yuankang Zou, Hong Tan, Tao Jiang, Angang Yang, Lintao Jia, Lei Wang. Journal of experimental & clinical cancer research : CR. 2021 Jan;40:12. [Full Text Article] [PubMed:33407675] [PMC:PMC7789733] Related Antibodies: LS-C97708.
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Antibodies (23)
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SOX4 (27)
Human (23)
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IHC (8)
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rabbit (20)
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monoclonal mc (3)
polyclonal pc (20)
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SOX4 Antibody - Formalin-fixed and paraffin-embedded human brain reacted with SOX4 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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SOX4 Antibody (aa86-114) LS-C97708
(4.0) Rating
(1) Publication(s)
SOX4 Rabbit anti-Human Polyclonal (aa86-114) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SOX4 Antibody - Immunohistochemistry of paraffin-embedded human brain tissue using SOX4 Antibody at dilution of 1:100
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SOX4 Antibody (aa1-60) LS-C499849
(4.0) Rating
(1) Publication(s)
SOX4 Rabbit anti-Human Polyclonal (aa1-60) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
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SOX4 Antibody (HRP) LS-C499850
SOX4 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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SOX4 Antibody (Biotin) LS-C499847
SOX4 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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SOX4 Antibody (FITC) LS-C499848
SOX4 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
SOX4 Antibody - Formalin-fixed and paraffin-embedded human brain reacted with SOX4 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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SOX4 Antibody (aa269-297) LS-C97709
SOX4 Rabbit anti-Human Polyclonal (aa269-297) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
SOX4 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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IHC-plus™ SOX4 Antibody LS-B12115
(4.0) Rating
SOX4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
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SOX4 Antibody LS-C75932
SOX4 Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
50 µg/$558
SOX4 Antibody - Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-SOX4 mAb.
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SOX4 Antibody (clone 154C4a) LS-C342673
SOX4 Mouse anti-Human Monoclonal (154C4a) Antibody
Human
DB, ICC, IF, WB
Unconjugated
100 µg/$486
SOX4 Antibody - SOX4 antibody Immunohistochemistry of Human Testis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SOX4 Antibody (N-Terminus) LS-C109764
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, WB
Unconjugated
100 µl/$424
SOX4 Antibody - SOX4 antibody Immunohistochemistry of Human Testis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SOX4 Antibody (N-Terminus, HRP) LS-C429245
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Gibbon, Human, Monkey, Chimpanzee
IHC, WB
HRP Conjugated
100 µl/$469
SOX4 Antibody - SOX4 antibody Immunohistochemistry of Human Testis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SOX4 Antibody (N-Terminus, Biotin) LS-C429243
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Gibbon, Human, Monkey, Chimpanzee
IHC, WB
Biotin Conjugated
100 µl/$469
SOX4 Antibody - SOX4 antibody Immunohistochemistry of Human Testis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SOX4 Antibody (N-Terminus, FITC) LS-C429244
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Gibbon, Human, Monkey, Chimpanzee
IHC, WB
FITC Conjugated
100 µl/$469
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SOX4 Antibody LS-C780954
SOX4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
SOX4 Antibody - Western blot analysis of SOX4 expression in HeLa cells lysate. The lane on the left is treated with the antigen-specific peptide.
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SOX4 Antibody LS-C804207
SOX4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SOX4 Antibody - Detection limit for recombinant GST tagged SOX4 is approximately 0.3 ng/ml as a capture antibody.
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SOX4 Antibody (clone 2C5) LS-C198245
SOX4 Mouse anti-Human Monoclonal (2C5) Antibody
Human
ELISA
Unconjugated
50 µg/$423
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SOX4 Antibody (Internal) LS-C50460
SOX4 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
WB
Unconjugated
50 µg/$495
SOX4 Antibody - Western blot of SOX4 Antibody with human MCF7 Whole Cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SOX4 Antibody (N-Terminus) LS-C345738
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
SOX4 Antibody - Western blot of SOX4 Antibody with human MCF7 Whole Cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SOX4 Antibody (N-Terminus, HRP) LS-C480585
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$469
SOX4 Antibody - Western blot of SOX4 Antibody with human MCF7 Whole Cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SOX4 Antibody (N-Terminus, Biotin) LS-C480583
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$469
SOX4 Antibody - Western blot of SOX4 Antibody with human MCF7 Whole Cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SOX4 Antibody (N-Terminus, FITC) LS-C480584
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$469
SOX4 Antibody
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SOX4 Antibody LS-C490292
SOX4 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$575
SOX4 Antibody - SOX4 antibody Western blot. All lanes: Anti SOX4 at 0.5 ug/ml. Lane 1: MCF-7 Whole Cell Lysate at 40 ug. Lane 2: 293T Whole Cell Lysate at 40 ug. Predicted band size: 47 kD. Observed band size: 47 kD.
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SOX4 Antibody (aa1-31) LS-C407831
SOX4 Rabbit anti-Human Polyclonal (aa1-31) Antibody
Mouse, Dog, Guinea pig, Sheep, Bovine, Pig, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
SOX4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Human SOX4 Protein (Recombinant GST, N-terminus) (aa45-136) - LS-G60176
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
SOX4 Protein - Purified recombinant protein SOX4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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Human SOX4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71044
HEK 293 Cells
Myc-DDK (Flag)
47.1 kDa
20 µg/$1,107
Viewing 1-25 of 27 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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