Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Locations
Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Telephone Numbers
Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
| Catalog Number | Size | Price |
|---|---|---|
| LS-B8169-50 | 50 µg (1 mg/ml) | $440 |
1 of 2
2 of 2
PathPlus™ Polyclonal Rabbit anti‑Human SOD2 / Mn SOD Antibody (IHC, WB) LS‑B8169
PathPlus™ Polyclonal Rabbit anti‑Human SOD2 / Mn SOD Antibody (IHC, WB) LS‑B8169
Note: This antibody replaces LS-C109053
Antibody:
SOD2 / Mn SOD Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IHC-P, WB, IP, ELISA
Reactivity:
Human, Monkey, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Pig, Rabbit, Sheep, Chicken, Xenopus, Gerbil
Format:
Unconjugated, Unmodified
Other formats:
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
SOD2 / Mn SOD Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IHC-P, WB, IP, ELISA
Reactivity:
Human, Monkey, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Pig, Rabbit, Sheep, Chicken, Xenopus, Gerbil
Format:
Unconjugated, Unmodified
Other formats:
Specifications
Description
SOD2 (superoxide dismutase 2, mitochondrial, MnSOD ) is a mitochondrial protein that converts toxic superoxide byproducts and to diatomic oxygen and hydrogen peroxide. It functions to clear reactive oxygen species in the mitochondria and thus it plays an important role in protecting against apoptosis, cell death and oxidative stress. Mutations in SOD2 may lead to a number of diseases including idiopathic cardiomyopathy, cancer, premature aging syndromes, and neurodegenerative diseases including Alzheimer’s, Parkinson’s, and sporadic motor neuron disease. In immunohistochemistry, SOD2 has granular cytoplasmic positivity in all tissues.
References: J Bio Chem. 278 (15): 13294–301. doi:10.1074/jbc.M208670200, PMID: 12551919; Biochemistry. 48 (15): 3417–24. doi:10.1021/bi8023288, PMID: 19265433; Free Radic Biol Med. 2013 Sep;62:4-12, PMID: 23727323
Target
Human SOD2 / Mn SOD
Synonyms
SOD2 | IPOB | MVCD6 | Indophenoloxidase B | Mn superoxide dismutase | MNSOD | Mangano-superoxide dismutase
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Pig, Rabbit, Sheep, Chicken, Xenopus, Gerbil
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Human Mn SOD.
Specificity
Detects 25kD protein, corresponding to the molecular mass of Mn superoxide dismutase (SOD) on SDS-PAGE immunoblots.
Applications
- IHC
- IHC - Paraffin (10 µg/ml)
- Western blot (0.2 µg/ml)
- Immunoprecipitation
- ELISA
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Western Blot: 0.2 ug/ml was sufficient for detection of Mn SOD in 20 ug of rat brain tissue extract.
Presentation
PBS, pH 7.4, 0.09% Sodium Azide, 50% Glycerol
Storage
Aliquot and freeze at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About SOD2 / Mn SOD
Validation
Anti-MNSOD / SOD2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-MNSOD / SOD2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-MNSOD / SOD2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-MNSOD / SOD2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
See More About...
LSBio Ratings
PathPlus™ SOD2 / Mn SOD Antibody for IHC, WB/Western, IP, ELISA LS-B8169 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, Western blot, ELISA
Species:
Rat, Human, Monkey, Mouse, Bovine, Dog, Guinea pig, Hamster, Pig, Rabbit, Sheep, Chicken, Xenopus, Drosophila
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation, ELISA
Species:
Human, Mouse, Rat, Bovine
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human, Mouse, Rat, Pig
Applications:
IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human
Applications:
IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/17/2024
Date Requested: 4/17/2024
