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Anti-SOD1 / Cu-Zn SOD Antibody (clone 2F5) IHC-plus™ LS-B3283

Note: This antibody replaces LS-C44971

Ordering

Wt. Vol. Conc. Price
50 µg - 1 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular SOD1 / Cu-Zn SOD Antibodies

Anti-SOD1 / Cu-Zn SOD Antibody LS-C86989
Rabbit Polyclonal to Human SOD1 / Cu-Zn SOD
Human
Western blot, Immunoprecipitation, ELISA
Unconjugated
Anti-SOD1 / Cu-Zn SOD Antibody IHC-plus™ LS-B2907
Rabbit Polyclonal to Human SOD1 / Cu-Zn SOD
Human, Mouse, Rat, Guinea pig, Horse
IHC - Paraffin, IHC - Frozen, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 2F5] (IgG1) to Bovine SOD1 / Cu-Zn SOD
Bovine, Human, Mouse
IHC - Paraffin, IHC - Frozen, ELISA
Unconjugated

Details

Bovine SOD1 / Cu-Zn SOD
Mouse
Bovine, Human, Mouse (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [2F5]
Unconjugated
Protein G purified
Unmodified

Applications

  • IHC - Paraffin (15 µg/ml)
  • IHC - Frozen
  • ELISA

Specificity and Use

SOD1 / Cu-Zn SOD antibody was raised against superoxide dismutase enzyme prepared from bovine erythrocytes.
Recognizes copper/zinc superoxide dismutase (SOD). Superoxide dismutases are ubiquitous metalloproteins that destroy oxygen-mediated free radicals, that are normally produced within the cells, which are toxic to biological systems. There are three forms of superoxide dismutase, including the Fe, mitochondrial (Mn) and the copper/zinc binding (Cu/Zn) form. The Cu/Zn form of SOD is utilized by most eukaryotic organisms. SOD Cu/Zn prevents oxygen-mediated free radical damage by catalyzing the dismutation of the toxic superoxide radical to molecular oxygen and hydrogen peroxide. Does not cross react with immunoglobulins but does react weakly with Mn SOD.
Immunohistochemistry: LS-B3283 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B3283 was determined to be 15 ug/ml. Histology Positive Control Tissue: Human spleen and lymph node.

Packaging

PBS with 0.1% sodium azide and 0.1% BSA. Sourced in TCS.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About SOD1 / Cu-Zn SOD

P00441 NM_000454 NP_000445.1

SOD1 Antibody, ALS Antibody, ALS1 Antibody, Cu/Zn superoxide dismutase Antibody, HSod1 Antibody, Homodimer Antibody, IPOA Antibody, SOD, soluble Antibody, SOD Antibody, Superoxide dismutase [Cu-Zn] Antibody, Superoxide dismutase 1 Antibody, Indophenoloxidase A Antibody, Superoxide dismutase, cystolic Antibody

SOD1 / Cu-Zn SOD binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis.

Immunohistochemistry

Immunohistochemistry
Anti-SOD1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3283 concentration 15 ug/ml.

Immunohistochemistry

Immunohistochemistry
Anti-SOD1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3283 concentration 15 ug/ml.

Requested From: United States
Date Requested: 12/11/2016

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