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SOCS2

suppressor of cytokine signaling 2

SOCS2 is a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.

Gene Name: suppressor of cytokine signaling 2
Synonyms: SOCS2, CIS-2, SOCS-2, STAT-induced STAT inhibitor 2, SSI2, CIS2, Cish2, SSI-2, STAT induced STAT inhibitor-2, STAT-induced STAT inhibitor-2, STATI2
Target Sequences: NM_003877 NP_003868.1 O14508

Publications (1)

1
IFN?-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment. Christopher J Nirschl, Mayte Suárez-Fariñas, Benjamin Izar, Sanjay Prakadan, Ruth Dannenfelser, Itay Tirosh, Yong Liu, Qian Zhu, K Sanjana P Devi, Shaina L Carroll, David Chau, Melika Rezaee, Tae-Gyun Kim, Ruiqi Huang, Judilyn Fuentes-Duculan, George X Song-Zhao, Nicholas Gulati, Michelle A Lowes, Sandra L King, Francisco J Quintana, Young-Suk Lee, James G Krueger, Kavita Y Sarin, Charles H Yoon, Levi Garraway, Aviv Regev, Alex K Shalek, Olga Troyanskaya, Niroshana Anandasabapathy. Cell. 2017 June;170:127-141.e15. [Full Text Article] [PubMed:28666115] [PMC:PMC5569303]

☰ Filters
Antibodies (36)
ELISA Kits (8)
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Over-Expression Lysate (2)
Primary (36)
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SOCS2 (51)
Human (30)
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rabbit (36)
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SOCS2 Antibody - Immunohistochemistry of paraffin-embedded Human brain using SOCS2 Polyclonal Antibody at dilution of 1:40.
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SOCS2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
SOCS2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SOCS2 Antibody - Immunohistochemistry of paraffin-embedded human lung using antibody at 1:100 dilution.
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SOCS2 Rabbit anti-Human Polyclonal (aa1-198) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
SOCS2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
SOCS2 Antibody - Staining 293T cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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SOCS2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SOCS2 Antibody - Immunofluorescent analysis of HepG2 cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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SOCS2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$294; 100 µg/$360
Select
SOCS2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
SOCS2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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SOCS2 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
SOCS2 Antibody - Western blot of SOCS-2 antibody
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SOCS2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
SOCS2 Antibody - Western blot analysis of lysate from Jurkat cells, using SOCS-2 antibody.
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SOCS2 Rabbit anti-Human Polyclonal (aa18-67) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
SOCS2 Antibody - Immunofluorescence analysis of U-2OS cells using SOCS2 Polyclonal Antibody at dilution of 1:100 (40x lens).Blue: DAPI for nuclear staining.
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SOCS2 Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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SOCS2 Rabbit anti-Human Polyclonal (aa181-198) Antibody
Rat, Human
WB
Unconjugated
100 µg/$380
SOCS2 Antibody - SOCS2 antibody Western blot of U937 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SOCS2 Rabbit anti-Human Polyclonal (aa117-166) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
SOCS2 Antibody - SOCS2 antibody Western blot of U937 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SOCS2 Rabbit anti-Human Polyclonal (aa117-166) (HRP) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100 µl/$469
SOCS2 Antibody - SOCS2 antibody Western blot of U937 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SOCS2 Rabbit anti-Human Polyclonal (aa117-166) (Biotin) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
SOCS2 Antibody - SOCS2 antibody Western blot of U937 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SOCS2 Rabbit anti-Human Polyclonal (aa117-166) (FITC) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100 µl/$469
SOCS2 Antibody - Western blot of SOCS2 antibody.
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SOCS2 Rabbit anti-Human Polyclonal (aa1-198) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
SOCS2 Antibody - Western blot of SOCS2 antibody.
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SOCS2 Rabbit anti-Human Polyclonal (aa1-198) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
SOCS2 Antibody - Western blot of SOCS2 antibody.
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SOCS2 Rabbit anti-Human Polyclonal (aa1-198) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676
SOCS2 Antibody - Western blot of SOCS2 antibody.
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SOCS2 Rabbit anti-Human Polyclonal (aa1-198) (Cy3) Antibody
Human
WB
Cy3 Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
SOCS2 Antibody - Western blot of SOCS2 antibody.
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SOCS2 Rabbit anti-Human Polyclonal (aa1-198) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
SOCS2 Antibody
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SOCS2 Rabbit anti-Human Polyclonal Antibody
Rat, Human
WB
Unconjugated
100 µg/$575
SOCS2 Antibody - Western blot analysis of SOCS2 expression in K562 (A); A204 (B); PC12 (C) whole cell lysates.
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SOCS2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human, Monkey
WB
Unconjugated
100 µl/$299
SOCS2 Antibody - antibody, PB, Western blot. All lanes: Anti SOCS2 at 0.5 ug/ml. Lane 1: PC-12 Whole Cell Lysate at 40 ug. Lane 2: SW620 Whole Cell Lysate at 40 ug. Lane 3: HELA Whole Cell Lysate at 40 ug. Lane 4: MCF-7 Whole Cell Lysate at 40 ug. Predicted band size: 22 kD. Observed band size: 22 kD.
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SOCS2 Rabbit anti-Human Polyclonal (aa96-198) Antibody
Rat, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
Viewing 1-25 of 51 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).