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Anti-SOCS1 Antibody (aa199-211) IHC-plus™ LS-B2488

Note: This antibody replaces LS-C55481

Ordering

Wt. Vol. Conc. Price
50 µg - 0.5 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular SOCS1 Antibodies

Anti-SOCS1 Antibody (C-Terminus) IHC-plus™ LS-B2697
Rabbit Polyclonal to Human SOCS1
Human, Mouse, Rat
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-SOCS1 Antibody (aa35-66) LS-C161380
Rabbit Polyclonal to Human SOCS1
Human, Mouse
IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Unconjugated
Immunohistochemistry Image
Anti-SOCS1 Antibody (clone 4H1) IHC-plus™ LS-B12231
Mouse Monoclonal [clone 4H1] (IgG1) to Mouse SOCS1
Mouse, Human
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry - Paraffin Image

100% Guaranteed 100% Guaranteed
Goat Polyclonal to Human SOCS1
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig, Rabbit
IHC - Paraffin, Western blot
Unconjugated

Details

Human SOCS1
Goat
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig, Rabbit (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • IHC - Paraffin (2.5 µg/ml)
  • Western blot (0.5 - 2 µg/ml)

Specificity and Use

SOCS1 antibody was raised against synthetic peptide C-VLRDYLSSFPFQI from the C-terminus of human SOCS1 (NP_003736.1). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Bat, Horse, Rabbit, Pig (100%); Gibbon (92%); Ferret, Opossum, Turkey, Chicken, Xenopus (85%).
LS-E25203 - Lyophilized - 100 µg - $145.00
aa199-211
Human SOCS1.
Immunohistochemistry: LS-B2488 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2488 was determined to be 2.5 ug/ml.

Packaging

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Store at -20°C. Minimize freezing and thawing.
For research use only.

About SOCS1

O15524 NM_003745 NP_003736.1

SOCS1 Antibody, CIS1 Antibody, CISH1 Antibody, JAB Antibody, JAK-binding protein Antibody, JAK binding protein Antibody, STAT-induced STAT inhibitor 1 Antibody, SSI-1 Antibody, Tec-interacting protein 3 Antibody, TIP3 Antibody, SOCS-1 Antibody, SSI1 Antibody, STAT induced SH3 protein 1 Antibody, TIP-3 Antibody

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF).

Immunohistochemistry

Immunohistochemistry
Anti-SOCS1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2488 concentration 5 ug/ml.

Western blot

Western blot
Antibody staining (2 ug/ml) of mouse spleen lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.

Requested From: United States
Date Requested: 12/3/2016

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