Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
SNX15 is a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene.
Gene Name: | sorting nexin 15 |
Family/Subfamily: | Sorting Nexin |
Synonyms: | SNX15, Clone iota unknown protein, Sorting nexin-15, Sorting nexin 15, HSAF001435 |
Target Sequences: | NM_013306 NP_037438.2 Q9NRS6 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.