Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG) to Human SNCA / Alpha-Synuclein
IHC - Frozen, Western blot
Human SNCA / Alpha-Synuclein
Human (tested or 100% immunogen sequence identity)
Tissue culture supernatant
IHC - Frozen
Specificity and Use
Recombinant human full length alpha synuclein.
Recognizes alpha Synuclein. By Western blot the antibody shows no reactivity with beta or gamma synuclein. This antibody was shown to stain Lewy bodies in frozen section of human brain with Parkinson's disease and glial inclusions in frozen section of human brain with Multiple System Atrophy. Species Reactivity: Human. Not recommended for use on rat.
Western blotting on recombinant alpha synuclein: 1:2000-1:4000. Immunohistochemistry (frozen sections): 1:250-1:500.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease.