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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SNCA / Alpha‑Synuclein Antibody (C‑Terminus) LS‑C11497
Alpha-Synuclein antibody LS-C11497 is an unconjugated goat polyclonal antibody to human Alpha-Synuclein (SNCA). Validated for ELISA and IHC.
Antibody
Catalog
Size
Price
LS-C11497-100
100 µl
$385

Popular SNCA / Alpha-Synuclein Products

Anti-SNCA / Alpha-Synuclein antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2923 concentration 10 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, ELISA
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Species: Human
Applications: IHC, IHC - Paraffin, Western blot, Immunoprecipitation
Antibody
Species: Human, Mouse, Rat
Applications: Immunofluorescence, Western blot, ELISA
Antibody
Species: Human
Applications: ELISA
Antibody
Species: Human, Mouse, Rat
Applications: IHC, Western blot, ELISA

Product Description

Alpha-Synuclein antibody LS-C11497 is an unconjugated goat polyclonal antibody to human Alpha-Synuclein (SNCA). Validated for ELISA and IHC.

Specifications

Target
Human SNCA / Alpha-Synuclein
Synonyms
SNCA, Alpha-synuclein, PARK4, PD1, Synuclein alpha-140, NACP, PARK1
Host
Goat
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Rat (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Antiserum
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:300)
  • ELISA (1:1000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic peptide corresponding to amino acids 116-131 of the C-terminus of a synuclein.
Epitope
C-Terminus
Specificity
Recognizes human alpha-synuclein. The alpha-synuclein gene, located on chromosome 4, has been linked to early onset autosomal dominant Parkinson's disease. The protein is abundant in the nervous system, and is known to be the precursor of the non-beta amyloid component protein (NACP) of Alzheimer's disease. Alpha-synuclein has also been found to be associated with other neurodegenerative diseases such as multiple system atrophy and dementia with Lewy's bodies.
Usage
Immunohistology: This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
Presentation
Serum, 0.09% Sodium Azide
Storage
Store at 4°C or -20°C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid freeze-thaw cycles as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Restrictions
For research use only.
About SNCA / Alpha-Synuclein
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. P37840 NM_000345 NP_000336.1


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Requested From: United States
Date Requested: 10/16/2018

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