Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Myofibroblast transdifferentiation of mesothelial cells is mediated by RAGE and contributes to peritoneal fibrosis in uraemia. De Vriese AS, Tilton RG, Mortier S, Lameire NH. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2006 21:2549-55.
SNAI1 Antibody, DJ710H13.1 Antibody, Protein sna Antibody, SNAIL Antibody, Snail 1 Antibody, Snail 1, zinc finger protein Antibody, Snail homolog 1 (Drosophila) Antibody, SNA Antibody, Snail 1 homolog Antibody, Protein snail homolog 1 Antibody, SNAH Antibody, Snail 1 zinc finger protein Antibody, Zinc finger protein SNAI1 Antibody, SLUGH2 Antibody, SNAIL1 Antibody
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription.
Formalin-fixed and paraffin-embedded human Spleen tissue reacted with SNAIL antibody (N-term D24) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
HepG2 cells were incubated with HGF for the time periods indicated. LiCl and MG132 were added 8 h before lysis of the cells. Snail protein levels and beta actin as loading control were analyzed by WB.
Western blot of SNAIL (arrow) using rabbit polyclonal hSNAIL-D24. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SNAIL gene (Lane 2).