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SNAI1 / SNAIL-1
snail family zinc finger 1
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
| Gene Name: | snail family zinc finger 1 |
| Synonyms: | SNAI1, DJ710H13.1, Protein sna, SNAIL, Snail 1, Snail 1, zinc finger protein, Snail homolog 1 (Drosophila), SNA, Snail 1 homolog, Protein snail homolog 1, SNAH, Snail 1 zinc finger protein, Zinc finger protein SNAI1, SLUGH2, SNAIL1 |
| Target Sequences: | NM_005985 NP_005976.2 O95863 |
Publications (6)
1
Myofibroblast transdifferentiation of mesothelial cells is mediated by RAGE and contributes to peritoneal fibrosis in uraemia. De Vriese AS, Tilton RG, Mortier S, Lameire NH. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2006 21:2549-55.
[PubMed:16757496]
Related Antibodies: LS-C97983.
2
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human)
[Full Text Article]
[PubMed:25870011]
[PMC:PMC4623112]
Related Antibodies: LS-C176686.
3
Employing an orthotopic model to study the role of epithelial-mesenchymal transition in bladder cancer metastasis. Roth B, Jayaratna I, Sundi D, Cheng T, Melquist J, Choi W, Porten S, Nitti G, Navai N, Wszolek M, Guo C, Czerniak B, McConkey D, Dinney C. Oncotarget. 2017 8:34205-34222. (WB; Human)
[Full Text Article]
[PubMed:27494900]
[PMC:PMC5470961]
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (aa215-264) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (Ala242) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (aa80-130) Antibody
Mouse, Dog, Horse, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
![SNAI1 / SNAIL-1 Antibody - Immunofluorescence of monoclonal antibody to SNAI1 on U-2 OS cell. [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/snai1-snail-1-antibody-clone-2g11-ls-c198229/146589_5085625.jpg)
SNAI1 / SNAIL-1 Mouse anti-Human Monoclonal (2G11) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$424
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (aa9-39) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (190-270 aa) Antibody
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
Fast Shipping
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
IHC-P
Unconjugated
50 µg/$460
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
SNAI1 / SNAIL-1 Mouse anti-Human Monoclonal (6D2) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$459
SNAI1 / SNAIL-1 Goat anti-Human Polyclonal (aa8-19) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (aa1-264) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (190-270 aa) Antibody
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (pSer246) Antibody
Mouse, Human
ICC, IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IHC-P
Unconjugated, Preservative Free
100 µl/$412
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (pSer246) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (aa9-39) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (aa9-39) (PE) Antibody
Human
FLISA, IHC, WB
PE Conjugated
200 µl/$952
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (pSer246) Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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