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Anti-SMYD2 Antibody (Leu148) LS-C178248

Catalog	Size	Price
LS-C178248-100	100 µl	Unavailable

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Details

Target:	Human SMYD2
Host:	Rabbit
Reactivity:	Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality:	Polyclonal
Conjugations:	Unconjugated
Purification:	Immunoaffinity purified
Modifications:	Unmodified

Applications

Approved:

Western blot

Specificity and Use

Immunogen:	SMYD2 antibody was raised against synthetic peptide around Leu148 of human SMYD2
Epitope:	Leu148
Specificity:	Human SMYD2

Packaging

Presentation:	PBS, pH 7.2, 0.05% sodium azide
Storage:	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Restrictions:	For research use only.

About SMYD2

Uniprot: Q9NRG4 NCBI: NM_020197 NP_064582.2

Synonyms: SMYD2 Antibody, HSKM-B Antibody, KMT3C Antibody, Lysine N-methyltransferase 3C Antibody, ZMYND14 Antibody

Description: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.

(More About SMYD2)

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Western blot

Western blot of SMYD2 (L148) pAb in extracts from HT29 cells.

Requested From:
Date Requested: 8/23/2017

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