SMG1 / ATX

SMG1 phosphatidylinositol 3-kinase-related kinase

Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.

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Products

Antibodies (25)

ELISA Kits (2)

Proteins (2)

Type

Custom (1)

Primary (25)

Recombinant (2)

Sandwich (1)

Target

SMG1 / ATX (29)

Reactivity

Human (26)

Mouse (2)

Rat (1)

Application

IHC (19)

IHC-P (2)

WB (6)

ELISA (20)

ICC (1)

IF (1)

IP (2)

Peptide-ELISA (1)

Host

rabbit (24)

mouse (1)

Isotype

IgG (23)

IgG1,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (24)

Clone

1C12 (1)

Format

96-Well Strip Plate (2)

APC Conjugated (3)

Azide-free (3)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (3)

Preservative Free (1)

Unconjugated (10)

Epitope

C-Terminus (7)

Internal (6)

N-Terminus (6)

aa1250-1300 (1)

aa1625-1675 (1)

aa2925-2975 (1)

Publications

No (29)

Sample Type

Plasma (1)

Serum (1)

Tag

GST, N-terminus (2)

Species

Human (2)

Source

Wheat Germ Extract (2)

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SMG1 / ATX Antibody (aa2925-2975) LS-C287285

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (aa2925-2975) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

20 µl/$295; 100 µl/$414

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SMG1 / ATX Antibody (clone 1C12) LS-C133700

Antibody:

SMG1 / ATX Mouse anti-Human Monoclonal (1C12) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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SMG1 / ATX Antibody (Preservative Free) LS-C815042

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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SMG1 / ATX Antibody (C-Terminus) LS-C328691

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

200 µl/$734

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SMG1 / ATX Antibody (C-Terminus, Biotin) LS-C282788

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Biotin Conjugated

Price:

200 µl/$952

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SMG1 / ATX Antibody (C-Terminus, FITC) LS-C282789

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

FITC Conjugated

Price:

200 µl/$952

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SMG1 / ATX Antibody (C-Terminus, APC) LS-C282787

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (C-Terminus) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

APC Conjugated

Price:

200 µl/$952

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SMG1 / ATX Antibody (C-Terminus, Azide-free, HRP) LS-C282790

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (C-Terminus) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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SMG1 / ATX Antibody (C-Terminus, PE) LS-C282791

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (C-Terminus) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

SMG1 / ATX Antibody (Internal) LS-C328693

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

200 µl/$734

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SMG1 / ATX Antibody (Internal, Biotin) LS-C282794

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

SMG1 / ATX Antibody (Internal, FITC) LS-C282795

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (Internal) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

FITC Conjugated

Price:

200 µl/$952

Select

SMG1 / ATX Antibody (Internal, APC) LS-C282793

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (Internal) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

APC Conjugated

Price:

200 µl/$952

Select

SMG1 / ATX Antibody (Internal, PE) LS-C282797

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (Internal) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

PE Conjugated

Price:

200 µl/$952

Select

SMG1 / ATX Antibody (Internal, Azide-free, HRP) LS-C282796

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (Internal) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

SMG1 / ATX Antibody (N-Terminus) LS-C330659

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

200 µl/$734

Select

SMG1 / ATX Antibody (N-Terminus, Biotin) LS-C282780

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

SMG1 / ATX Antibody (N-Terminus, FITC) LS-C282782

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

FITC Conjugated

Price:

200 µl/$952

Select

SMG1 / ATX Antibody (N-Terminus, APC) LS-C282783

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (N-Terminus) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

APC Conjugated

Price:

200 µl/$952

Select

SMG1 / ATX Antibody (N-Terminus, PE) LS-C282785

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (N-Terminus) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

PE Conjugated

Price:

200 µl/$952

Select

SMG1 / ATX Antibody (N-Terminus, Azide-free, HRP) LS-C282784

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (N-Terminus) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

SMG1 / ATX Antibody (C-Terminus) LS-C46851

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$379

Select

SMG1 / ATX Antibody (aa1250-1300) LS-C288327

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (aa1250-1300) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$514

Select

SMG1 / ATX Antibody LS-C803830

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

SMG1 / ATX Antibody (aa1625-1675) LS-C287283

Antibody:

SMG1 / ATX Rabbit anti-Human Polyclonal (aa1625-1675) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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