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Anti-SMC1A / SMC1 Antibody (phospho-Ser957) LS-C39294

Catalog Size Price
LS-C39294-200 200 µg Unavailable

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64 SMC1A / SMC1 Antibodies

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100% Guaranteed
Mouse Monoclonal (IgG1) to Human SMC1A / SMC1
Human, Monkey, Bovine, Dog, Rabbit
Western blot (applications tested for the base form of this product only)
Unconjugated

Details

Human SMC1A / SMC1
Mouse
Human, Monkey, Bovine, Dog, Rabbit (tested or 100% immunogen sequence identity)
IgG1 Monoclonal
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Protein G purified
Unmodified

Applications

  • Western blot (1 - 2 µg/ml)
  • (applications tested for the base form of this product only)

Specificity and Use

SMC1A / SMC1 antibody was raised against kLH-conjugated, synthetic peptide corresponding to amino acids 951-962 SQEEGS[pS]QGEDS) of human SMC1 (Structural Maintenance of Chromosome 1). The immunizing sequence is identical in bovine and has 11/12 identical amino acids in mouse and xenopus.
pSer957
Recognizes phospho-SMC1 (Ser957), Mr 150kD. Species cross-reactivity: Human and mouse. Predicted to cross-react with Xenopus and bovine based on sequence homology.
Suitable for use in Western Blot. Western Blot: 1-2 ug/ml detects phospho-SMC1 in RIPA lysates from irradiated GMO536 cells and hydroxyurea treated HEK293 cells. Cell lysates from untreated and irradiated GMO536 cells were resolved by electrophoresis, transferred to nitrocellulose and probed with anti-phospho-SMC1 (Ser957) (2 ug/ml). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a chemiluminescence detection system.

Packaging

0.1 M Tris-glycine, pH 7.4, 0.15 M sodium chloride, 0.05% sodium azide, 30% glycerol.
For research use only.

About SMC1A / SMC1

Q14683 NM_006306 NP_006297.2

SMC1A Antibody, CDLS2 Antibody, DXS423E Antibody, KIAA0178 Antibody, SB1.8 Antibody, SMC protein 1A Antibody, SMC1 Antibody, SMC1L1 Antibody, SMC-1-alpha Antibody, SMC-1A Antibody, SMCB Antibody

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain.

Requested From: 
Date Requested: 10/23/2017

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