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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SMC1A / SMC1 Antibody (phospho‑Ser957) LS‑C39294
Antibody
SMC1 antibody LS-C39294 is an unconjugated mouse monoclonal antibody to SMC1 (SMC1A) from human, bovine, dog and other species. Validated for WB.
Catalog
Size
Price
LS-C39294-200
200 µg
Unavailable

Popular SMC1A / SMC1 Products

Antibody
Species: Human, Mouse, Xenopus
Applications: Immunofluorescence, Western blot, Immunoprecipitation
Anti-SMC1A / SMC1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5432 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, ELISA
IHC of paraffin-embedded human colon using SMC1 mouse monoclonal antibody with DAB staining.
Species: Human
Applications: IHC, Immunofluorescence, Western blot, Flow Cytometry, ELISA
Anti-SMC1A / SMC1 antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11029 dilution 1:100.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Immunofluorescence
Anti-SMC1A / SMC1 antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11277 concentration 5 ug/ml.
Species: Human, Mouse, Rat, Bovine, Dog, Guinea pig, Horse, Rabbit, Chicken, Xenopus laevis
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, Immunoprecipitation, Proximity Ligation Assay

Product Description

SMC1 antibody LS-C39294 is an unconjugated mouse monoclonal antibody to SMC1 (SMC1A) from human, bovine, dog and other species. Validated for WB.
About SMC1A / SMC1
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Q14683 NM_006306 NP_006297.2

SMC1A Antibody, CDLS2 Antibody, DXS423E Antibody, KIAA0178 Antibody, SB1.8 Antibody, SMC protein 1A Antibody, SMC1 Antibody, SMC1L1 Antibody, SMC-1-alpha Antibody, SMC-1A Antibody, SMCB Antibody


Specifications

Target
Human SMC1A / SMC1
Host
Mouse
Reactivity
Human, Monkey, Bovine, Dog, Rabbit (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • Western blot (1 - 2 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
SMC1A / SMC1 antibody was raised against kLH-conjugated, synthetic peptide corresponding to amino acids 951-962 SQEEGS[pS]QGEDS) of human SMC1 (Structural Maintenance of Chromosome 1). The immunizing sequence is identical in bovine and has 11/12 identical amino acids in mouse and xenopus.
Epitope
pSer957
Specificity
Recognizes phospho-SMC1 (Ser957), Mr 150kD. Species cross-reactivity: Human and mouse. Predicted to cross-react with Xenopus and bovine based on sequence homology.
Usage
Suitable for use in Western Blot. Western Blot: 1-2 ug/ml detects phospho-SMC1 in RIPA lysates from irradiated GMO536 cells and hydroxyurea treated HEK293 cells. Cell lysates from untreated and irradiated GMO536 cells were resolved by electrophoresis, transferred to nitrocellulose and probed with anti-phospho-SMC1 (Ser957) (2 ug/ml). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a chemiluminescence detection system.
Presentation
0.1 M Tris-glycine, pH 7.4, 0.15 M sodium chloride, 0.05% sodium azide, 30% glycerol.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/21/2018

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