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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SMAD6 Antibody (aa137‑182) LS‑C31183
SMAD6 antibody LS-C31183 is an unconjugated rabbit polyclonal antibody to SMAD6 from human, mouse, rat and other species. Validated for IHC and WB.
Catalog
Size
Price
LS-C31183-100
100 µg (1 mg/ml)
Unavailable

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Product Description

SMAD6 antibody LS-C31183 is an unconjugated rabbit polyclonal antibody to SMAD6 from human, mouse, rat and other species. Validated for IHC and WB.
About SMAD6
Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. O43541 NM_005585 NP_005576.3

SMAD6 Antibody, AOVD2 Antibody, HSMAD6 Antibody, HsT17432 Antibody, SMAD 6 Antibody, MADH7 Antibody, Mothers against DPP homolog 6 Antibody, SMAD family member 6 Antibody, MAD homolog 6 Antibody, MADH6 Antibody


Specifications

Target
Human SMAD6
Host
Rabbit
Reactivity
Human, Mouse, Rat, Bovine, Dog, Pig (tested or 100% immunogen sequence identity)
Predicted
Monkey, Guinea pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with Biotin, HRP, FITC.
Purification
Protein A/G purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • Western blot (0.5 - 1 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
SMAD6 antibody was raised against synthetic peptide located between aa137-182 of human SMAD6 (O43541, NP_005576). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Galago, Mouse, Rat, Elephant, Dog, Bovine, Pig, Opossum (100%); Marmoset, Guinea pig (92%); Zebrafish (85%).
Epitope
aa137-182
Specificity
Human SMAD6
Presentation
Lyophilized from PBS with 2% sucrose
Reconstitution
100 µl After adding water, will consist of PBS buffer with 2% sucrose
Storage
Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human lung.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human lung. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human heart.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human heart. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Jurkat Cell Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human lung.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human lung. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human heart.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human heart. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Jurkat Cell Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human lung.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human lung. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human heart.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human heart. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Jurkat Cell Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human lung.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human lung. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human heart.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SMAD6 antibody LS-C31183 was used in IHC to stain formalin-fixed, paraffin-embedded human heart. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Jurkat Cell Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.


Requested From: 
Date Requested: 6/22/2018

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