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SMAD3
SMAD family member 3
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
| Gene Name: | SMAD family member 3 |
| Synonyms: | SMAD3, HSPC193, HMAD-3, HsT17436, LDS1C, LDS3, Mad homolog JV15-2, MAD3, MADH3, Mothers against DPP homolog 3, JV15-2, SMA- and MAD-related protein 3, SMAD family member 3, MAD homolog 3, HSMAD3, Mad protein homolog, SMAD 3 |
| Target Sequences: | NM_005902 NP_005893.1 P84022 |
Publications (4)
1
Zinc supplementation attenuates ethanol- and acetaldehyde-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS) production and by influencing intracellular signaling. Szuster-Ciesielska A, Plewka K, Daniluk J, Kandefer-Szersze M. Biochemical pharmacology. 2009 78:301-14. (WB)
[PubMed:19376089]
2
Characterization of articular cartilage homeostasis and the mechanism of superior cartilage regeneration of MRL/MpJ mice. Zhenhan Deng, Xueqin Gao, Xuying Sun, Sarah Amra, Aiping Lu, Yan Cui, Holger K Eltzschig, Guanghua Lei, Johnny Huard. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 Aug;33:8809-8821. [Full Text Article]
[PubMed:31042406]
Related Antibodies: LS-B64.
3
YAP and TAZ are required for the postnatal development and the maintenance of the structural integrity of the oviduct. Philippe Godin , Mayra Tsoi , Marilène Paquet , Derek Boerboom. Reproduction (Cambridge, England). 2020 Aug;;160:307-318. [Full Text Article]
[PubMed:32520726]
Related Antibodies: LS-B64.
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SMAD3 Rabbit anti-Human Polyclonal (pSer423/425) Antibody
Xenopus laevis, Xenopus tropicalis, Chicken, Zebrafish, Pig, Bovine, Mouse, Rat, Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$515
SMAD3 Rabbit anti-Human Polyclonal (aa100-150) Antibody
Mouse, Dog, Bovine, Rat, Pig, Macaque, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$460
Sandwich
96-Well Strip Plate
Mouse, Human, Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$854
DNA Binding Phosphorylation
12 x 8-Well Microstrips
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$735
SMAD3 Mouse anti-Human Monoclonal (2C12) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
SMAD3 Rabbit anti-Human Polyclonal (aa186-215) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SMAD3 Rabbit anti-Human Polyclonal (pSer213) Antibody
Chicken, Rat, Pig, Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
SMAD3 Rabbit anti-Human Polyclonal (120-200 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
SMAD3 Rabbit anti-Human Polyclonal (pThr179) Antibody
Mouse, Dog, Sheep, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$315
SMAD3 Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Sheep, Rat, Pig, Mouse, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
SMAD3 Mouse anti-Human Monoclonal (7F3) Antibody
Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
SMAD3 Rabbit anti-Human Polyclonal (pSer208) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SMAD3 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
SMAD3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
SMAD3 Rabbit anti-Human Monoclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, Flo, IF, IP, WB
Unconjugated
100 µl/$688
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
50.3kD
10 µg/$277; 50 µg/$395; 500 µg/$1,262; 1 mg/$1,627
SMAD3 Rabbit anti-Human Polyclonal (pSer204) Antibody
Chicken, Sheep, Rat, Pig, Mouse, Human, Monkey
ICC, IF, IP, WB
Unconjugated
100 µl/$315
SMAD3 Rabbit anti-Human Polyclonal (aa376-425) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
SMAD3 Rabbit anti-Human Polyclonal (aa 174-223) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
SMAD3 Rabbit anti-Human Polyclonal (pThr179) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
SMAD3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$328
SMAD3 Rabbit anti-Human Polyclonal (aa186-215) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
SMAD3 Rabbit anti-Human Polyclonal (aa186-215) (APC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
SMAD3 Rabbit anti-Human Polyclonal (aa186-215) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
SMAD3 Rabbit anti-Human Polyclonal (aa186-215) (PE) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
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