Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey, Bat, Bovine, Dog, Rabbit, Chicken, Xenopus
Western blot, ELISA
Human, Monkey, Bat, Bovine, Dog, Rabbit, Chicken, Xenopus (tested or 100% immunogen sequence identity)
Hamster, Zebrafish (at least 90% immunogen sequence identity)
Western blot (1 - 3 µg/ml)
IHC - Paraffin
Specificity and Use
SMAD2 antibody was raised against synthetic peptide SEIWGLSTPNTIDC from an internal region of human SMAD2 (NP_005892.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog, Bat, Bovine, Rabbit, Opossum, Chicken, Platypus, Xenopus (100%); Hamster, Stickleback, Zebrafish (92%); Mouse, Rat, Pufferfish (85%).
SMAD2 Antibody, HMAD-2 Antibody, HSMAD2 Antibody, JV18-1 Antibody, Mad protein homolog smad2 Antibody, MADR2 Antibody, MADH2 Antibody, SMAD 2 Antibody, MAD homolog 2 Antibody, Mad-related protein 2 Antibody, JV18 Antibody, Mother against DPP homolog 2 Antibody, Mothers against DPP homolog 2 Antibody, Sma- and Mad-related protein 2 Antibody, SMAD family member 2 Antibody
SMAD2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation.