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SMAD1

SMAD family member 1

SMAD1 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

Gene Name: SMAD family member 1
Synonyms: SMAD1, BSP1, BSP-1, JV4-1, MADH1, Mothers against DPP homolog 1, JV41, SMAD family member 1, TGF-beta signaling protein 1, MADR1, HSMAD1, MAD homolog 1, Mad-related protein 1, SMAD 1
Target Sequences: NM_005900 NP_005891.1 Q15797

Publications (5)

1
Axotomy-induced Smad1 activation promotes axonal growth in adult sensory neurons. Zou H, Ho C, Wong K, Tessier-Lavigne M. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 29:7116-23. (WB, IP) [PubMed:19494134] [PMC:PMC2739099]
2
Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. Li X, Rhee DK, Malhotra R, Mayeur C, Hurst LA, Ager E, Shelton G, Kramer Y, McCulloh D, Keefe D, Bloch KD, Bloch DB, Peterson RT. The Journal of clinical investigation. 2016 126:389-401. (WB; Human) [Full Text Article] [PubMed:26657863] [PMC:PMC4701562] Related Antibodies: LS-C75853.
3
BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Shahid M, Spagnolli E, Ernande L, Thoonen R, Kolodziej SA, Leyton PA, Cheng J, Tainsh RE, Mayeur C, Rhee DK, Wu MX, Scherrer-Crosbie M, Buys ES, Zapol WM, Bloch KD, Bloch DB. American journal of physiology. Heart and circulatory physiology. 2016 April;310:H984-H994. [Full Text Article] [PubMed:26873969] [PMC:PMC4867336] Related Antibodies: LS-C75853.
4
Transforming growth factor-ß stimulates Smad1/5 signaling in pulmonary artery smooth muscle cells and fibroblasts of the newborn mouse through ALK1. Huili Zhang, Lili Du, Ying Zhong, Kathleen C Flanders, Jesse D Roberts Jr. American journal of physiology. Lung cellular and molecular physiology. 2017 September;313:L615-L627. [Full Text Article] [PubMed:28642261] [PMC:PMC5625261] Related Antibodies: LS-C75853.
5
The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6. Mayeur C, Lohmeyer LK, Leyton P, Kao SM, Pappas AE, Kolodziej SA, Spagnolli E, Yu B, Galdos RL, Yu PB, Peterson RT, Bloch DB, Bloch KD, Steinbicker AU. Blood. Apr;123:2261-8. [Full Text Article] [PubMed:24501215] [PMC:PMC3975261] Related Antibodies: LS-C75853.
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SMAD1 Antibody LS-C75853
(4.3) Rating
(4) Publication(s)
SMAD1 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
Flo, ICC, IP, WB
Unconjugated
50 µg/$558
SMAD1 Protein - 12.5% SDS-PAGE of human SMAD1 stained with Coomassie Blue
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Human SMAD1 Protein (Recombinant GST) (Full Length) - LS-G29239
Wheat Germ Extract
GST
76.89 kDa
10 µg/$479; 25 µg/$670
SMAD1 ELISA Kit
Select
Mouse/Human/Rat Phospho-SMAD1 (Ser465) (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F925
DNA Binding Phosphorylation
12 x 8-Well Microstrips
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$735
SMAD1 Antibody - Immunohistochemical analysis of SMAD1 (pS187) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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SMAD1 Antibody (phospho-Ser187) LS-C352485
SMAD1 Rabbit anti-Human Polyclonal (pSer187) Antibody
Chicken, Sheep, Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$315
SMAD1 Antibody - SMAD1 antibody SMAD1(SMAD family member 1) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human skin. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SMAD1 Antibody (N-Terminus) LS-C80224
SMAD1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
SMAD1 Antibody - Anti-SMAD1 antibody IHC staining of human intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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IHC-plus™ SMAD1 Antibody (aa153-202) LS-B9239
(4.0) Rating
SMAD1 Rabbit anti-Human Polyclonal (aa153-202) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
SMAD1 Antibody - Immunofluorescence of monoclonal antibody to SMAD1 on HeLa cell. [antibody concentration 10 ug/ml]
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SMAD1 Antibody (clone 2E9) LS-C133299
SMAD1 Mouse anti-Human Monoclonal (2E9) Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$423
SMAD1 Antibody - Immunofluorescence of monoclonal antibody to SMAD1 on HeLa cell. [antibody concentration 10 ug/ml]
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SMAD1 Antibody (clone 1D3) LS-C133298
SMAD1 Mouse anti-Human Monoclonal (1D3) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
SMAD1 Antibody - Immunofluorescent staining using SMAD1 antibody. Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.01% Triton-X100 in PBS. The cells were immunostained with anti-SMAD1 antibody.
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SMAD1 Antibody (clone 913C1b) LS-C184471
SMAD1 Mouse anti-Human Monoclonal (913C1b) Antibody
Mouse, Rat, Human
DB, Flo, ICC, IP, WB
Unconjugated
100 µg/$965
SMAD1 Antibody - Immunohistochemistry analysis of paraffin-embedded human heart tissue, using Smad1 Antibody. The picture on the right is blocked with the synthesized peptide.
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SMAD1 Antibody (aa416-465) LS-C117539
SMAD1 Rabbit anti-Human Polyclonal (aa416-465) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
SMAD1 Antibody - Western blot of Phospho-Smad1 (S465) antibody
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SMAD1 Antibody (400-480 aa) LS-C381185
SMAD1 Rabbit anti-Human Polyclonal (400-480 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
SMAD1 Antibody - Immunohistochemistry (IHC) analysis of p-Smad1 (S465) pAb in paraffin-embedded human heart tissue.
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SMAD1 Antibody (phospho-Ser465) LS-C192196
SMAD1 Rabbit anti-Human Polyclonal (pSer465) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$328; 100 µl/$419
SMAD1 Antibody - Anti-SMAD1 Antibody - Western Blot. Western blot of Affinity Purified anti-SMAD1 antibody shows detection of endogenous SMAD1 in whole cell lysates from human hepatoma (HEPG2, lanes 1-4) and keratinocyte (HaCaT, lanes 5-8) derived cell lines treated with PBS, BMP2, EGF, or NaCl for 1 h at 37?C before harvest. Each lane contains approximately 15 ug of lysate. Primary antibody was used at a 1:500 dilution in 1% BLOTTO (B501-0500) and reacted for 1 hour at room temperature. Anti-beta actin (p/n LS-B323) staining was used as a loading control. The membrane was washed and reacted with a 1:3000 dilution HRP-conjugated a-Rabbit IgG (p/n LS-C60865) for 1 hour at room temperature. Detection was by ECL. Personal communication, Xin-Hua Feng, Baylor College of Medicine, Houston, TX.
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SMAD1 Antibody LS-C154249
SMAD1 Rabbit anti-Human Polyclonal Antibody
Mouse, Dog, Rat, Human
ELISA, IP, WB
Unconjugated
100 µg/$567
SMAD1 Antibody - Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-SMAD1 mAb.
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SMAD1 Antibody (clone 913C1b) LS-C342518
SMAD1 Mouse anti-Human Monoclonal (913C1b) Antibody
Mouse, Rat, Human
DB, Flo, ICC, IF, IP, WB
Unconjugated
100 µg/$486
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SMAD1 Antibody (phospho-Ser206, clone D40B7) LS-C184123
SMAD1 Rabbit anti-Human Monoclonal (pSer206) (D40B7) Antibody
Mouse, Rat, Human, Monkey
IP, WB
Unconjugated
20 µl/$483; 100 µl/$763
SMAD1 Antibody - 1:100 staining mouse muscle tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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SMAD1 Antibody (phospho-Ser187) LS-C801200
SMAD1 Rabbit anti-Human Polyclonal (pSer187) Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SMAD1 Antibody - SMAD1 antibody. IHC(P): Human Lung Cancer Tissue.
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SMAD1 Antibody (aa253-267) LS-C313543
SMAD1 Rabbit anti-Mouse Polyclonal (aa253-267) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
SMAD1 Antibody - A: Marker, B: Jurkat Cell Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SMAD1 Antibody (C-Terminus) LS-C31108
SMAD1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
SMAD1 Antibody - Immunohistochemical of paraffin-embedded H. heart section using SMAD1 Antibody. Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
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SMAD1 Antibody (aa163-196) LS-C344277
SMAD1 Rabbit anti-Human Polyclonal (aa163-196) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SMAD1 Antibody - 1:100 staining mouse muscle tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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SMAD1 Antibody LS-C801652
SMAD1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SMAD1 Antibody - 1:100 staining human lung carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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SMAD1 Antibody (phospho-Ser465) LS-C801199
SMAD1 Rabbit anti-Human Polyclonal (pSer465) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SMAD1 Antibody - SMAD1 Antibody staining SMAD1 in human skeletal muscle tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
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SMAD1 Antibody (clone 1356CT119.18.55) LS-C757687
SMAD1 Mouse anti-Human Monoclonal (1356CT119.18.55) Antibody
Human
ELISA, IF, IHC-P, WB
Unconjugated
200 µl/$393
SMAD1 Antibody - Immunohistochemistry of paraffin-embedded human heart tissue at dilution 1:100
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SMAD1 Antibody LS-C679536
SMAD1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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SMAD1 Antibody LS-C755265
SMAD1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
SMAD1 Antibody - Human, Colon: Formalin-Fixed Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SMAD1 Antibody (aa153-202) LS-B10841
SMAD1 Rabbit anti-Human Polyclonal (aa153-202) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
Viewing 1-25 of 181 product results



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