Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal (IgG) to Human SLPI / Antileukoproteinase
IHC, Western blot, ELISA
Goat Polyclonal (IgG) to Human SLPI / Antileukoproteinase
IHC - Paraffin, Western blot, Neutralization
Human SLPI / Antileukoproteinase
Human (tested or 100% immunogen sequence identity)
IHC - Paraffin (5 - 15 µg/ml)
Western blot (0.1 µg/ml)
Specificity and Use
E. coli-derived recombinant human SLPI.
Detects human SLPI in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with mouse SLPI is observed.
Western Blot, 0.1 µg/ml, Recombinant Human SLPI. Immunohistochemistry, 5-15 µg/ml, Immersion fixed paraffin-embedded sections of human skin. Neutralization, Measured by its ability to neutralize Recombinant Human SLPI (0.125 µg/ml) inhibition of. Trypsin (0.5 µg/ml) cleavage of the fluorogenic peptide substrate Mca-RPKPVE-Nval-WRK(Dnp)-N H2 (10 uM). The Neutralization Dose (ND50) is typically 1.5 µg/ml.
Lyophilized from 0.2 um filtered solution in PBS, trehalose
Sterile PBS. Resuspend to 500 ul
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
SLPI is a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity.