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| Catalog Number | Size | Price |
|---|---|---|
| LS-B4345-50 | 50 µg (0.5 mg/ml) | $485 |
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PathPlus™ Polyclonal Goat anti‑Human SLC7A11 / XCT Antibody (aa215‑229, IHC, IF, WB) LS‑B4345
PathPlus™ Polyclonal Goat anti‑Human SLC7A11 / XCT Antibody (aa215‑229, IHC, IF, WB) LS‑B4345
Note: This antibody replaces LS-C55476
Antibody:
SLC7A11 / XCT Goat anti-Human Polyclonal (aa215-229) Antibody
Application:
IHC, IHC-P, IF, WB, Peptide-ELISA
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
SLC7A11 / XCT Goat anti-Human Polyclonal (aa215-229) Antibody
Application:
IHC, IHC-P, IF, WB, Peptide-ELISA
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Specifications
Description
SLC7A11 (cystine/glutamate transporter, Xc-, xCT) is a chloride-dependent cystine-glutamate antiporter involved in excitatory signaling, glutamate release and modulation of synaptic activity. In addition to glutamatergic neurotransmission, it is thought to support neuroprotective processes related to oxidative stress. Dysfunctional glutamate signaling in neurological disorders such as schizophrenia may involve impairment of SLC7A11. In immunohistochemistry, SLC7A11 has high expression in astrocytes of the basolateral amygdala and prefrontal cortex in the brain, and it is also found in the eye, with low levels of additional expression in immune, reproductive and gastrointestinal tissues.
References: Pharmacological Reviews. 64 (3): 780–802, PMID: 22759795; Journal of Psychiatric Research. 72: 58–63, PMID: 26540405; Glia. 2018 May;66(5):951-970, PMID: 29350434; NPJ Schizophr. 2017 Sep 18;3(1):31, PMID: 28924227; Antioxid Redox Signal. 2013 Feb 10; 18(5): 522–555, PMID: 22667998
Target
Human SLC7A11 / XCT
Synonyms
SLC7A11 | CCBR1 | Cystine/glutamate transporter | XCT | SLC711
Host
Goat
Reactivity
Human, Monkey
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Modifications
Unmodified
Immunogen
Peptide with sequence C-KGQTQNFKDAFSGRD, from the internal region of the protein sequence according to NP_055146.1.
Epitope
aa215-229
Specificity
Human SLC7A11.
Applications
- IHC
- IHC - Paraffin (3.75 µg/ml)
- Immunofluorescence (10 µg/ml)
- Western blot (0.03 - 0.3 µg/ml)
- Peptide Enzyme-Linked Immunosorbent Assay (1:128000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
TBS, pH 7.3, 0.02% Sodium Azide, 0.5% BSA
Storage
Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About SLC7A11 / XCT
Validation
Anti-SLC7A11 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Anti-SLC7A11 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Anti-SLC7A11 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Anti-SLC7A11 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
See More About...
LSBio Ratings
PathPlus™ SLC7A11 / XCT Antibody (aa215-229) for IHC, IF/Immunofluorescence, WB/Western LS-B4345 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (1)
Increased Expression of System xc- in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance. Polewski MD, Reveron-Thornton RF, Cherryholmes GA, Marinov GK, Cassady K, Aboody KS. Molecular cancer research : MCR. 2016 December;14:1229-1242. (Human)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
Western blot, Flow Cytometry
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/18/2024
Date Requested: 4/18/2024
