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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SLC4A1 / Band 3 / AE1 Antibody LS‑C11866
AE1 antibody LS-C11866 is an unconjugated mouse monoclonal antibody to human AE1 (SLC4A1 / Band 3). Validated for ELISA and WB.
Antibody
Catalog
Size
Price
LS-C11866-100
100 µl
$755

Popular SLC4A1 / Band 3 / AE1 Products

Anti-Band 3 antibody IHC of human placenta, erythrocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1837 concentration 10 ug/ml.
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Product Description

AE1 antibody LS-C11866 is an unconjugated mouse monoclonal antibody to human AE1 (SLC4A1 / Band 3). Validated for ELISA and WB.

Specifications

Target
Human SLC4A1 / Band 3 / AE1
Synonyms
SLC4A1, Anion exchanger 1, Anion exchanger-1, AE1, Anion exchange protein 1, Band 3, Band 3 anion transport protein, BND3, CD233, DI, EPB3, AE 1, Froese blood group, FR, RTA1A, SW, Swann blood group, WD1, WR, Wright blood group, WD, CD233 antigen, EMPB3, Waldner blood group
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal
Conjugations
Unconjugated
Purification
Ascites
Modifications
Unmodified
Applications
  • Western blot (1:1000 - 1:5000)
  • ELISA (1:10000 - 1:50000)
Immunogen
Purified human Anion Exchanger 1 (AE1, Band3).
Specificity
Recognizes human Anion Exchanger 1 (AE-1, Band3). Does not recognize non-erythroid band-3 from human fibroblasts. Species cross-reactivity: Does not recognize band-3 from equine, mouse, bovine, porcine, guinea pig, canine or mouse erythrocytes.
Usage
Suitable for use in ELISA and Western Blot. Western Blot: 1:1000-1:5000. AE1 is ~90-100kD protein. It aggregates easily forming dimers and multimers. Aggregation may be avoided if membranes are prepared in N-ethylmaleimide. It may also be proteolytically processed to smaller fragments of 60, 40 and 20kD. ELISA: 1:10000-1:50000.
Presentation
PBS, 0.05% Sodium Azide, 40% Glycerol
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About SLC4A1 / Band 3 / AE1
SLC4A1 / Band 3 / AE1 is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. P02730 NM_000342 NP_000333.1


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Requested From: United States
Date Requested: 10/22/2018

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