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Anti-SLC25A27 / UCP4 Antibody (aa271-283) LS-C41564


Wt. Vol. Conc. Price
- 1000 µl 1.4 mg/ml Unavailable

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Rabbit Polyclonal (IgG) to Human SLC25A27 / UCP4
Western blot, ELISA


Human SLC25A27 / UCP4
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Ammonium sulfate precipitation


  • Western blot

Specificity and Use

SLC25A27 / UCP4 antibody was raised against synthetic peptide from human SLC25A27 / UCP4.
Recognizes human mitochondrial uncoupling protein 4, also known as uncoupling Protein 4, UCP 4, Solute carrier family 25 member 27 or SLC25A27. Uncoupling protein 4 is a 323 amino acid, ~36kD multiple pass, inner mitochondrial transmembrane protein bearing three repeats Uncoupling protein expression appears to be primarily associated with mitochondria of the central nervous system, with no protein being found in a number of peripheral organs when tested in immunohistochemistry, or western blotting in mice and rats. In mice uncoupling protein 4 appears in early to mid embryonic development coinciding with the initiation of neuronal differentiation and expression in mitochondria decreases with age, hinting at a possible role in neuronal differentiation. UCP4 facilitates the dissipation of heat across the inner mitochondrial membrane, by leaking protons across the membrane and uncoupling oxidative phosphorylation from ATP synthesis, the action of uncoupling protein 4 increasing proton concentration in the mitochondrial matrix may thus serve to increase ATP production by the class II complex. UCP4 is understood to be involved in thermoregulatory heat production and metabolism in brain.


Serum, PBS, 0.09% sodium azide.
For research use only.

About SLC25A27 / UCP4

O95847 NM_004277 NP_004268.3

SLC25A27 Antibody, RP11-446F17.2 Antibody, UCP 4 Antibody, UCP4 Antibody, Uncoupling protein 4 Antibody

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane.

Requested From: 
Date Requested: 4/25/2017

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