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worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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SLC11A2 / DMT1 antibody was raised against a 19 aa Peptide sequence located at the predicted cytoplasmic loop # 4 of rat NRAMP2 was synthesized, coupled to KLH.
4th Cytoplasmic Domain
Recognizes rat Natural Resistance Associated Macrophage Protein (Nramp2). 100% conserved in mouse, 94% in human, 73% in zebra fish NRAMP2. This sequence is common in NRAMP2 with or without IRE isoforms. This antibody will not distinguish between these isoforms.
Suitable for use in ELISA, Western Blot. Western Blot: 1-10 ug/ml using ECL technique. ELISA: 0.5-1 ug/ml Use 1 ug/ml control peptide/well.
PBS, pH 7.5, 0.1% BSA.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.
Solute carrier family 11, member 2 (SLCA2) also known as divalent metal ion transporter 1 (DMT1) imports Fe2+ via a proton-coupled, membrane potential dependent manner. It can also transport a variety of other divalent metal cations including Mn2+, Co2+, Cu2+, and Zn2+ but iron appears to be its most important physiological substrate.