Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 2E9/13] (IgG2b) to Pig SLA Class II DR
IHC - Frozen, Immunoprecipitation, Flow Cytometry (applications tested for the base form of this product only)
Pig SLA Class II DR
Pig, Bovine (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [2E9/13]
Also available conjugated with FITC.
Protein G purified
IHC - Frozen
(applications tested for the base form of this product only)
Specificity and Use
SLA Class II DR antibody was raised against porcine monocytes.
The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In pigs, this is referred to as the swine leukocyte antigen (SLA) region. There are 3 major MHC class II proteins encoded by the SLA which are SLA DP, SLA DQ and SLA DR. Clone 2E9/13 is specific for SLA DR molecules which are expressed on all B cells, antigen presenting cells and on certain subsets of resting and activated T cells. This clone reacts with lymphocytes from all outbred and miniature pigs so far tested, suggesting that it recognizes a monomorphic determinant of porcine SLA DR. Immunoprecipitates a heterodimer composed of two polypeptides of 28 and 35kD from NP-40 extracts of biotin surface-labeled porcine peripheral blood mononuclear cells. Clone 2E9/13 is reported to inhibit the mixed lymphocyte reaction and T cell stimulation induced by African swine fever virus and Staphylococcal enterotoxin B, see for details.
PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
Pig peripheral blood lymphocytes stained with Mouse anti-Pig SLA Class II DR followed by Goat anti-Mouse IgG:FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.