SKP1

S-phase kinase-associated protein 1

Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2. SCF(FBXO10) direct ubiquitination of BCL2.

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Proteins (11)

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SKP1 (60)

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IHC-plus™ SKP1 Antibody (aa152-163) LS-B422

(5.0) Rating

(1) Publication(s)

Antibody:

SKP1 Rabbit anti-Human Polyclonal (aa152-163) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$515

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SKP1 Antibody LS-C37973

Antibody:

SKP1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$786

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SKP1 Antibody (clone 4E+11) LS-C169443

Antibody:

SKP1 Mouse anti-Human Monoclonal (4E+11) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$459

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SKP1 Antibody (aa58-87, APC) LS-C245878

Antibody:

SKP1 Rabbit anti-Human Polyclonal (aa58-87) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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IHC-plus™ SKP1 Antibody (clone 1H9) LS-B10728

(4.0) Rating

Antibody:

SKP1 Mouse anti-Human Monoclonal (1H9) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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IHC-plus™ SKP1 Antibody (aa41-90) LS-B7623

(4.0) Rating

Antibody:

SKP1 Rabbit anti-Human Polyclonal (aa41-90) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

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SKP1 Antibody (clone 4E+11) LS-C758983

Antibody:

SKP1 Mouse anti-Human Monoclonal (4E+11) Antibody

Reactivity:

Mouse, Human, Non-Human Primate

Applications:

Flo, ICC, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$541

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SKP1 Antibody (aa151-163) LS-C89071

Antibody:

SKP1 Rabbit anti-Human Polyclonal (aa151-163) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Horse, Rat, Hamster, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey

Applications:

ELISA, WB

Format:

Unconjugated

Price:

1 mg/$901

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SKP1 Antibody LS-C155330

Antibody:

SKP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$450

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SKP1 Antibody (aa2-163, HRP) LS-C370347

Antibody:

SKP1 Rabbit anti-Human Polyclonal (aa2-163) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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SKP1 Antibody (clone 1H9) LS-C758475

Antibody:

SKP1 Mouse anti-Human Monoclonal (1H9) Antibody

Reactivity:

Rat, Non-Human Primate, Human

Applications:

Flo, IHC, WB

Format:

Unconjugated

Price:

100 µl/$503

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SKP1 Antibody (clone 1H8) LS-C198204

Antibody:

SKP1 Mouse anti-Human Monoclonal (1H8) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

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Human SKP1 Protein (Recombinant GST) (Full Length) - LS-G21191

Source:

E. coli

Tag:

GST

Molecular Weight:

34.52 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human SKP1 Protein (Recombinant) - LS-G653

Source:

E. coli

Tag:

None

Price:

100 µg/$342; 500 µg/$641; 20 µg/$254

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SKP1 Antibody LS-C404283

Antibody:

SKP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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SKP1 Antibody LS-C155251

Antibody:

SKP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Xenopus, Chicken, Bovine, Rat, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

Select

SKP1 Antibody LS-C751909

Antibody:

SKP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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SKP1 Antibody (aa1-163) LS-C373427

Antibody:

SKP1 Rabbit anti-Human Polyclonal (aa1-163) Antibody

Reactivity:

Rat, Pig, Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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SKP1 Antibody (10-90 aa, Internal) LS-C386085

Antibody:

SKP1 Rabbit anti-Human Polyclonal (10-90 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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SKP1 Antibody LS-C826723

Antibody:

SKP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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SKP1 Antibody LS-C747604

Antibody:

SKP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

SKP1 Antibody (aa1-163) LS-C376635

Antibody:

SKP1 Rabbit anti-Human Polyclonal (aa1-163) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

SKP1 Antibody LS-C668717

Antibody:

SKP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

Select

SKP1 Antibody (Pro72) LS-C176558

Antibody:

SKP1 Rabbit anti-Human Polyclonal (Pro72) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

SKP1 Antibody LS-C341303

Antibody:

SKP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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