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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SKIL / SNO / SnoN Antibody (aa553‑602) LS‑C146290
SnoN antibody LS-C146290 is an unconjugated rabbit polyclonal antibody to SnoN (SKIL / SNO) from human, mouse, rat and other species. Validated for WB.
Catalog
Size
Price
LS-C146290-50
50 µg
Unavailable

Popular SKIL / SNO / SnoN Products

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Product Description

SnoN antibody LS-C146290 is an unconjugated rabbit polyclonal antibody to SnoN (SKIL / SNO) from human, mouse, rat and other species. Validated for WB.
About SKIL / SNO / SnoN
SKIL / SNO / SnoN is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. P12757 NM_005414 NP_005405.2

SKIL Antibody, Ski-related oncogene Antibody, SnoI Antibody, SnoN Antibody, SKI-like oncogene Antibody, Sno Antibody, Ski-related oncogene snoN Antibody, Ski-related protein Antibody, Ski-like protein Antibody, SnoA Antibody


Specifications

Target
Mouse SKIL / SNO / SnoN
Host
Rabbit
Reactivity
Mouse, Human, Monkey, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Chicken, Zebrafish (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with Biotin, FITC, HRP.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot
  • (applications tested for the base form of this product only)
Immunogen
Synthetic peptide located between aa553-602 of mouse Skil (Q3TB81, NP_001034179). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Galago, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bovine, Bat, Rabbit, Horse, Pig, Opossum, Guinea pig, Turkey, Zebra finch, Chicken, Lizard (100%); Marmoset, Xenopus (85%); Zebrafish (81%).
Blocking Peptide
LS-E21249 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C146290. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa553-602
Specificity
Mouse SKIL
Presentation
Lyophilized from PBS with 2% sucrose
Reconstitution
Distilled water
Storage
Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Western blot

SKIL antibody LS-C146290 Western blot of Mouse Spleen lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SKIL antibody LS-C146290 Western blot of Mouse Spleen lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

SKIL antibody LS-C146290 Western blot of Mouse Spleen lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SKIL antibody LS-C146290 Western blot of Mouse Spleen lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

SKIL antibody LS-C146290 Western blot of Mouse Spleen lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SKIL antibody LS-C146290 Western blot of Mouse Spleen lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

SKIL antibody LS-C146290 Western blot of Mouse Spleen lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SKIL antibody LS-C146290 Western blot of Mouse Spleen lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.


Requested From: 
Date Requested: 6/19/2018

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