SIRT7 / Sirtuin 7

sirtuin 7

NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.

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Products

Antibodies (56)

ELISA Kits (8)

Proteins (8)

Type

Custom (4)

Development Kit (1)

Over-Expression Lysate (2)

Primary (56)

Recombinant (6)

Sandwich (3)

Target

SIRT7 / Sirtuin 7 (72)

Reactivity

Human (43)

Mouse (11)

Rat (29)

Bat (3)

Bovine (6)

Chimpanzee (6)

Dog (6)

Gibbon (3)

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IHC (20)

IHC-P (7)

WB (49)

Flo (1)

ELISA (16)

ICC (1)

IF (4)

Peptide-ELISA (1)

Host

rabbit (52)

mouse (3)

chicken (1)

Product Group

DevKit DuoPlus (1)

IHCPlus (3)

Isotype

IgG (20)

IgG1 (3)

IgY (1)

Clonality

monoclonal mc (3)

polyclonal pc (53)

Clone

1E2B2 (1)

1E2G10 (1)

Format

96-Well Strip Plate (7)

Antibody Pair and Standard (1)

APC (3)

APC Conjugated (4)

Azide-free (1)

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PE Conjugated (4)

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Epitope

aa1-400 (8)

aa135-274 (8)

aa275-397 (8)

aa331-360 (7)

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aa317-366 (4)

N-Terminus (1)

aa8-350 (1)

Publications

No (72)

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Cell Culture Supernatants (3)

Cell Lysates (3)

Plasma (1)

Serum (1)

Tissue Homogenates (4)

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GST (1)

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His (2)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Rat (2)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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IHC-plus™ SIRT7 / Sirtuin 7 Antibody LS-B2061

(4.0) Rating

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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SIRT7 / Sirtuin 7 Antibody (aa317-366) LS-B1566

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal (aa317-366) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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SIRT7 / Sirtuin 7 Antibody (aa317-366, HRP) LS-C427848

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal (aa317-366) (HRP) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Chimpanzee, Human

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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SIRT7 / Sirtuin 7 Antibody (aa317-366, Biotin) LS-C427846

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal (aa317-366) (Biotin) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Chimpanzee, Human

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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SIRT7 / Sirtuin 7 Antibody (aa317-366, FITC) LS-C427847

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal (aa317-366) (FITC) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Chimpanzee, Human

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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Human SIRT7 / Sirtuin 7 (Sandwich ELISA) ELISA Kit - LS-F33947

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$768

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SIRT7 / Sirtuin 7 Antibody LS-C404282

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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SIRT7 / Sirtuin 7 Antibody LS-C755281

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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IHC-plus™ SIRT7 / Sirtuin 7 Antibody (aa331-360) LS-B6912

(4.0) Rating

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal (aa331-360) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

Select

SIRT7 / Sirtuin 7 Antibody LS-C502012

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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SIRT7 / Sirtuin 7 Antibody LS-C770625

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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SIRT7 / Sirtuin 7 Antibody (clone 1E2G10) LS-C669358

Antibody:

SIRT7 / Sirtuin 7 Mouse anti-Human Monoclonal (1E2G10) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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SIRT7 / Sirtuin 7 Antibody LS-C482246

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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SIRT7 / Sirtuin 7 Antibody (aa331-360) LS-C330657

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal (aa331-360) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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SIRT7 / Sirtuin 7 Antibody (aa331-360, Biotin) LS-C226353

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal (aa331-360) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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SIRT7 / Sirtuin 7 Antibody (aa331-360, FITC) LS-C226354

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal (aa331-360) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

SIRT7 / Sirtuin 7 Antibody (aa331-360, APC) LS-C226352

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal (aa331-360) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

SIRT7 / Sirtuin 7 Antibody (aa331-360, PE) LS-C226356

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal (aa331-360) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

SIRT7 / Sirtuin 7 Antibody (aa331-360, Azide-free, HRP) LS-C226355

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal (aa331-360) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

SIRT7 / Sirtuin 7 Antibody (aa8-350) LS-C357545

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal (aa8-350) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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SIRT7 / Sirtuin 7 Antibody (clone 1E2B2) LS-C669334

Antibody:

SIRT7 / Sirtuin 7 Mouse anti-Human Monoclonal (1E2B2) Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

Unconjugated

Price:

100 µl/$459

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SIRT7 / Sirtuin 7 Antibody LS-C806007

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

SIRT7 / Sirtuin 7 Antibody LS-C192303

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

SIRT7 / Sirtuin 7 Antibody LS-C772849

Antibody:

SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

60 µl/$307; 120 µl/$367; 200 µl/$457

Select

SIRT7 / Sirtuin 7 Antibody (N-Terminus) LS-C10187

Antibody:

SIRT7 / Sirtuin 7 Mouse anti-Human Monoclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

150 µg/$842

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