Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Western blot (2 µg/ml)
Specificity and Use
SIRT7 / Sirtuin 7 antibody was raised against synthetic peptide made to an internal portion of the human protein (within residues 100-200). [Swiss-Prot# Q9NRC8]. Percent identity by BLAST analysis: Bovine, Porcine (88%).
SIRT7 Antibody, SIR2L7 Antibody, Sirtuin type 7 Antibody, SIR2-like protein 7 Antibody, Sir2-related protein type 7 Antibody, Sirtuin 7 Antibody
NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor.