SIRT6 / Sirtuin 6

sirtuin 6

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate.

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Products

Antibodies (76)

Proteins (10)

ELISA Kits (6)

Type

Custom (2)

Over-Expression Lysate (2)

Primary (76)

Recombinant (8)

Sandwich (4)

Target

SIRT6 / Sirtuin 6 (92)

Reactivity

Human (64)

Mouse (27)

Rat (15)

Bat (3)

Bovine (3)

Chimpanzee (3)

Dog (6)

Hamster (3)

Monkey (4)

Pig (3)

Application

IHC (27)

IHC-P (13)

WB (72)

Flo (1)

ELISA (22)

IF (3)

IP (3)

Peptide-ELISA (1)

Host

rabbit (68)

mouse (7)

chicken (1)

Product Group

IHCPlus (4)

Isotype

IgG (24)

IgG1 (6)

IgG2b,k (1)

IgY (1)

Clonality

monoclonal mc (7)

polyclonal pc (69)

Clone

2G1E8 (1)

2G1H1 (1)

OTI1G3 (2)

S6R82-2 (1)

Format

96-Well Strip Plate (6)

APC (3)

APC Conjugated (5)

Biotin Conjugated (9)

Carrier-free (1)

Cy3 Conjugated (3)

Cy7 Conjugated (3)

DY488 Conjugated (2)

DY550 Conjugated (2)

DY650 Conjugated (2)

FITC Conjugated (7)

HRP Conjugated (7)

PE Conjugated (5)

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C-Terminus (9)

aa1-355 (9)

aa1-334 (8)

aa88-288 (8)

aa276-305 (7)

aa290-319 (7)

Internal (4)

aa56-105 (4)

aa14-180 (1)

aa250-350 (1)

aa300-355 (1)

aa305-320 (1)

aa305-355 (1)

aa50-100 (1)

aa88-352 (1)

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Publications

No (89)

Yes (3)

Sample Type

Cell Culture Supernatants (2)

Cell Lysates (2)

Plasma (3)

Serum (3)

Tissue Homogenates (4)

Tag

GST (1)

GST, N-terminus (2)

His (4)

Myc-DDK (Flag) (3)

Species

Human (7)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Select

SIRT6 / Sirtuin 6 Antibody (aa56-105) LS-B5589

(4.2) Rating

(3) Publication(s)

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa56-105) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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SIRT6 / Sirtuin 6 Antibody (aa56-105, HRP) LS-C427854

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa56-105) (HRP) Antibody

Reactivity:

Mouse, Dog, Hamster, Pig, Bat, Chimpanzee, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$442

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SIRT6 / Sirtuin 6 Antibody (aa56-105, Biotin) LS-C427852

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa56-105) (Biotin) Antibody

Reactivity:

Mouse, Dog, Hamster, Pig, Bat, Chimpanzee, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$442

• Unconjugated
• HRP
• Biotin

• Unconjugated
• HRP
• Biotin

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IHC-plus™ SIRT6 / Sirtuin 6 Antibody (aa305-320) LS-B900

(5.0) Rating

(1) Publication(s)

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa305-320) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

Select

SIRT6 / Sirtuin 6 Antibody (aa290-319) LS-C100492

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa290-319) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Human SIRT6 / Sirtuin 6 (Sandwich ELISA) ELISA Kit - LS-F7874

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$834

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SIRT6 / Sirtuin 6 Antibody (C-Terminus) LS-B5588

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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Human SIRT6 / Sirtuin 6 (Sandwich ELISA) ELISA Kit - LS-F52611

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

3.12 - 200 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$958

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SIRT6 / Sirtuin 6 Antibody (aa14-180) LS-C357546

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa14-180) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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SIRT6 / Sirtuin 6 Antibody (Internal, Biotin) LS-C141047

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

0.1 ml/$416

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IHC-plus™ SIRT6 / Sirtuin 6 Antibody (aa50-100) LS-B15070

(4.0) Rating

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa50-100) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP

Format:

Unconjugated

Price:

50 µl/$460

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Human SIRT6 / Sirtuin 6 Protein (Recombinant His) (aa1-355) - LS-G15594

Source:

E. coli

Tag:

His

Molecular Weight:

44.8 kDa

Price:

10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,728

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Mouse SIRT6 / Sirtuin 6 (Sandwich ELISA) ELISA Kit - LS-F8958

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$854

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SIRT6 / Sirtuin 6 Antibody (aa290-319) LS-C328678

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa290-319) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

SIRT6 / Sirtuin 6 Antibody (aa276-305) LS-C330141

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa276-305) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

SIRT6 / Sirtuin 6 Antibody (aa276-305, Biotin) LS-C520462

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa276-305) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

SIRT6 / Sirtuin 6 Antibody (aa276-305, FITC) LS-C269475

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa276-305) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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SIRT6 / Sirtuin 6 Antibody (aa276-305, APC) LS-C269474

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa276-305) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

SIRT6 / Sirtuin 6 Antibody (aa276-305, PE) LS-C269476

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa276-305) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE

Select

SIRT6 / Sirtuin 6 Antibody LS-C751670

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

SIRT6 / Sirtuin 6 Antibody (C-Terminus) LS-C75839

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IF, IP, WB

Format:

Unconjugated

Price:

100 µl/$688

Select

SIRT6 / Sirtuin 6 Antibody LS-C349129

Antibody:

SIRT6 / Sirtuin 6 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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SIRT6 / Sirtuin 6 Antibody (clone 2G1H1) LS-C669325

Antibody:

SIRT6 / Sirtuin 6 Mouse anti-Human Monoclonal (2G1H1) Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

Unconjugated

Price:

100 µl/$459

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SIRT6 / Sirtuin 6 Antibody LS-C813116

Antibody:

SIRT6 / Sirtuin 6 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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SIRT6 / Sirtuin 6 Antibody (clone OTI1G3) LS-C173370

Antibody:

SIRT6 / Sirtuin 6 Mouse anti-Human Monoclonal (OTI1G3) Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

100 µl/$434

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