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SIRT3 / Sirtuin 3
sirtuin 3
SIRT3 / Sirtuin 3 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.
| Gene Name: | sirtuin 3 |
| Family/Subfamily: | ADP-Ribosyltransferase , not assigned-ADP-Ribosyltransferase |
| Synonyms: | SIRT3, HSIRT3, Sir2-like 3, SIR2-like protein 3, SIR2L3, Sirtuin 3, Sirtuin type 3 |
| Target Sequences: | NM_012239 NP_036371.1 Q9NTG7 |
Publications (2)
1
FoxO1 mediates an autofeedback loop regulating SIRT1 expression. Xiong S, Salazar G, Patrushev N, Alexander RW. The Journal of biological chemistry. 2011 286:5289-99.
[PubMed:21149440]
[PMC:PMC3037641]
Related Antibodies: LS-C100489.
2
Integration of -catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity. Parker JA, Vazquez-Manrique RP, Tourette C, Farina F, Offner N, Mukhopadhyay A, Orfila AM, Darbois A, Menet S, Tissenbaum HA, Neri C. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:12630-40.
[PubMed:22956852]
Related Antibodies: LS-C100489.
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SIRT3 / Sirtuin 3 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
0.1 mg/$379
SIRT3 / Sirtuin 3 Goat anti-Mouse Polyclonal (aa170-183) Antibody
Mouse, Rat, Pig
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$503
SIRT3 / Sirtuin 3 Rabbit anti-Human Polyclonal (aa250-279) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
SIRT3 / Sirtuin 3 Rabbit anti-Human Monoclonal Antibody
Rat, Human
ELISA, IP, WB
Unconjugated
100 µl/$688
SIRT3 / Sirtuin 3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
SIRT3 / Sirtuin 3 Rabbit anti-Human Polyclonal (aa20-130) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
E. coli
His
30.1 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
SIRT3 / Sirtuin 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
SIRT3 / Sirtuin 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SIRT3 / Sirtuin 3 Mouse anti-Human Monoclonal (aa126-382) (PE) Antibody
Human
ICC, IP, WB
PE Conjugated
100 µl/$418; 200 µl/$507; 500 µl/$887; 1 ml/$1,051; 2 ml/$1,383; 5 ml/$2,591
SIRT3 / Sirtuin 3 Mouse anti-Human Monoclonal (6B2A1) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
SIRT3 / Sirtuin 3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
SIRT3 / Sirtuin 3 Rabbit anti-Human Polyclonal (aa56-84) Antibody
Human
WB
Unconjugated
400 µl/$393
SIRT3 / Sirtuin 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SIRT3 / Sirtuin 3 Rabbit anti-Human Polyclonal (aa20-130) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
SIRT3 / Sirtuin 3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
E. coli
His-T7
32.3 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$854
SIRT3 / Sirtuin 3 Rabbit anti-Mouse Polyclonal (aa304-334) Antibody
Mouse, Hamster, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$393
SIRT3 / Sirtuin 3 Rabbit anti-Mouse Polyclonal (aa304-334) Antibody
Mouse, Hamster
ELISA, IHC, WB
Unconjugated
200 µl/$734
SIRT3 / Sirtuin 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
SIRT3 / Sirtuin 3 Rabbit anti-Human Polyclonal (aa250-279) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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