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Anti-SIRT1 / Sirtuin 1 Antibody (aa207-256) IHC-plus™ LS-B1564

Note: This antibody replaces LS-C30198


Wt. Vol. Conc. Price
50 µg - 1 mg/ml $450
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Alternate Forms of this Antibody

LS-C427801 Biotin Conjugated
LS-C427802 FITC Conjugated
LS-C427803 HRP Conjugated

Most Popular SIRT1 / Sirtuin 1 Antibodies

Anti-SIRT1 / Sirtuin 1 Antibody (aa207-256) IHC-plus™ LS-B1564
Rabbit Polyclonal (IgG) to Human SIRT1 / Sirtuin 1
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit, Zebrafish
IHC - Paraffin, Western blot
Immunohistochemistry Image
Anti-SIRT1 / Sirtuin 1 Antibody (clone 7B7) IHC-plus™ LS-B4520
Mouse Monoclonal [clone 7B7] (IgG1,k) to Human SIRT1 / Sirtuin 1
IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Immunohistochemistry Image
Anti-SIRT1 / Sirtuin 1 Antibody (aa577-590) IHC-plus™ LS-B8356
Goat Polyclonal to Human SIRT1 / Sirtuin 1
Human, Monkey
IHC - Paraffin, Western blot, ELISA
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed Publications Publications (2)
Rabbit Polyclonal (IgG) to Human SIRT1 / Sirtuin 1
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit, Zebrafish
IHC - Paraffin, Western blot (applications tested for the base form of this product only)


Human SIRT1 / Sirtuin 1
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit, Zebrafish (tested or 100% immunogen sequence identity)
Xenopus (at least 90% immunogen sequence identity)
IgG Polyclonal
Immunoaffinity purified


  • IHC - Paraffin (5 µg/ml)
  • Western blot (0.5 µg/ml)
  • (applications tested for the base form of this product only)

Specificity and Use

SIRT1 / Sirtuin 1 antibody was raised against synthetic peptide located between aa207-256 of human SIRT1 (Q96EB6, NP_036370). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Elephant, Dog, Bovine, Bat, Rabbit, Horse, Pig, Guinea pig (100%); Turkey, Xenopus (92%); Chicken (85%); Zebrafish (84%).
LS-E11337 - Lyophilized - 100 µg - $145.00
human SIRT1
Immunohistochemistry: LS-B1564 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B1564 was determined to be 5 ug/ml.


Lyophilized from PBS with 2% sucrose
Distilled water
Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than one week): +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

Publications (2)

Notochordal cell disappearance and modes of apoptotic cell death in a rat tail static compression-induced disc degeneration model. Yurube T, Hirata H, Kakutani K, Maeno K, Takada T, Zhang Z, Takayama K, Matsushita T, Kuroda R, Kurosaka M, Nishida K. Arthritis research & therapy. 2014 16:R31. [Full Text Article] [PubMed:24472667] [PMC:PMC3979117]
Age-dependent increase in miRNA-34a expression in the posterior pole of the mouse eye. Smit-McBride Z, Forward KI, Nguyen AT, Bordbari MH, Oltjen SL, Hjelmeland LM. Molecular vision. 20:1569-78. [Full Text Article] [PubMed:25489229] [PMC:PMC4225137]

About SIRT1 / Sirtuin 1

Q96EB6 NM_012238 NP_036370.2

SIRT1 Antibody, SIR2-like protein 1 Antibody, SIR2alpha Antibody, SIR2L1 Antibody, Sirtuin 1 Antibody, Sir2-like 1 Antibody, Sirtuin type 1 Antibody, HSIR2 Antibody, HSIRT1 Antibody

The SIRT family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes including transcriptional regulation, cell cycle progression, DNA damage repair and aging. Sirtuins utilize NAD+ as a substrate to catalyze deacetylation of specific acetylated protein and histones. SIRT1 has been shown to be induced by caloric restriction (CR) in several tissues and SIRT1 mediated deacetylase activity attenuates B-amyloid content in the brain during CR.


Anti-SIRT1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1564 concentration 5 ug/ml. This image was taken for the base form of this product. Alternate forms, such as conjugated, azide-free, or ready-to-use, have not been tested.

Requested From: United States
Date Requested: 10/22/2016

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