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Anti-SIRPA / CD172a Antibody (clone 15-414) LS-C58098

Note: This antibody replaces LS-C58100, LS-C58095


Wt. Vol. Conc. Price
100 µg - 1 mg/ml $270
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular SIRPA / CD172a Antibodies

Anti-SIRPA / CD172a Antibody (C-Terminus) IHC-plus™ LS-B551
Rabbit Polyclonal (IgG) to Human SIRPA / CD172a
Human, Mouse, Rat
IHC - Paraffin, ICC, Western blot
Immunohistochemistry Image
Anti-SIRPA / CD172a Antibody (clone 7B3) LS-C340387
Mouse Monoclonal [clone 7B3] (IgG1) to Human SIRPA / CD172a
IHC - Paraffin, Western blot
Immunohistochemistry Image
Anti-SIRPA / CD172a Antibody (C-Terminus) LS-C353657
Rabbit Polyclonal to Human SIRPA / CD172a
Human, Monkey
ICC, Immunofluorescence, Western blot, Immunoprecipitation
Immunofluorescence Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 15-414] (IgG2a) to Human SIRPA / CD172a
IHC - Frozen, Flow Cytometry (applications tested for the base form of this product only)


Human SIRPA / CD172a
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [15-414]
Affinity purified


  • IHC - Frozen (1:100)
  • Flow Cytometry (1:100 - 1:200)
  • (applications tested for the base form of this product only)

Specificity and Use

SIRPA / CD172a antibody was raised against monocyte-derived dendritic cells.
Specific for human CD172a, also known as signal-regulatory protein alpha, a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and hematopoietic stem cells. CD172a acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. Ligand binding of CD172a to integrin-associated protein CD47, results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of CD172a, mediating the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. These then act as regulators of cellular function, through dephosphorylation of specific substrates.
Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul. Method sheets are available on request.


PBS, 0.09% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
For research use only.

About SIRPA / CD172a

P78324 NM_080792 NP_542970.1

SIRPA Antibody, CD172A Antibody, CD172a antigen Antibody, Inhibitory receptors shps-1 Antibody, Inhibitory receptor SHPS-1 Antibody, Macrophage fusion receptor Antibody, MyD-1 antigen Antibody, p84 Antibody, SHPS-1 Antibody, SHPS1 Antibody, SIRP Antibody, Sirp-alpha-1 Antibody, Sirp-alpha-3 Antibody, Sirp-alpha1 Antibody, MYD1 Antibody, SIRPalpha Antibody, SIRPalpha2 Antibody, BIT Antibody, MFR Antibody, MYD-1 Antibody, PTPNS1 Antibody, SHP substrate 1 Antibody, Sirp-alpha-2 Antibody

CD172A / SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases.

Requested From: United States
Date Requested: 10/26/2016

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