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Anti-SIP / TP53INP1 Antibody (aa1-14) LS-C83545

Catalog Size Price
LS-C83545-100 100 µg Unavailable

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Anti-SIP / TP53INP1 Antibody (aa140-220) LS-C386470
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100% Guaranteed
Rabbit Polyclonal to Human SIP / TP53INP1
Human, Mouse, Rat
Western blot


Human SIP / TP53INP1
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Immunoaffinity purified


Western blot (1 - 2 µg/ml)

Specificity and Use

SIP / TP53INP1 antibody was raised against peptide corresponding to aa 1-14 of human p53DINP1. This sequence is identical in p53DINP1 alpha and beta and differs from that of mouse p53DINP1 by one amino acid.
Recognizes human, mouse, and rat p53DINP1 (p53- Dependent Damage-Inducible Nuclear Protein 1), a p53 inducible gene. A p53DINP1 antisense oligonucleotide inhibits, and overexpression of p53DINP1 enhances, Ser46 phosphorylation of p53, induction of p53AIP1, and cell death induced by DNA double-strand breaks. The p53DINP1 gene encodes two proteins of 27 and 18 kD designated p53DINP1- a and p53DINP1-~. p53DINP1 is expressed in many tissues and is induced by stress agents.
Western Blot: 1-2 ug/ml. In immunoblots on human lung tissue lysate, a band of 27 kD is detected. A lower molecular weight band is detected at 18 kD in human spleen and mouse liver and kidney tissue lysates which probably represents p53DINP1-beta.


PBS, pH 7.4, 0.02% sodium azide
4°C or -20°C, Avoid freeze-thaw cycles.
For research use only.

About SIP / TP53INP1

Q96A56 NM_033285 NP_150601.1

TP53INP1 Antibody, p53DINP1 Antibody, SIP Antibody, Teap Antibody, TP53DINP1 Antibody, TP53INP1A Antibody, p53-inducible p53DINP1 Antibody, Stress-induced protein Antibody, TP53INP1B Antibody

Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response.

Requested From: 
Date Requested: 5/22/2018

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