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SIM2

single-minded family bHLH transcription factor 2

This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.

Gene Name: single-minded family bHLH transcription factor 2
Synonyms: SIM2, BHLHe15, HMC29C01, HMC13F06, Transcription factor SIM2, Single-minded homolog 2, SIM
Target Sequences: NM_005069 NP_005060.1 Q14190

☰ Filters
Antibodies (14)
Proteins (2)
Over-Expression Lysate (2)
Primary (14)
SIM2 (16)
Human (14)
Mouse (4)
Rat (3)
Chicken (3)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
Monkey (3)
Rabbit (3)
Xenopus (3)
Zebrafish (3)
IHC (5)
IHC-P (5)
WB (10)
ELISA (4)
IP (1)
Peptide-ELISA (1)
rabbit (11)
mouse (2)
goat (1)
IgG (8)
IgG2a,k (1)
monoclonal mc (2)
polyclonal pc (12)
3E6 (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (8)
N-Terminus (4)
aa426-526 (1)
aa428-437 (1)
No (16)
Myc-DDK (Flag) (2)
Human (1)
293T Cells (1)
HEK 293 Cells (1)
SIM2 Antibody - SIM2 antibody Western blot of Fetal Kidney lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SIM2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$424
SIM2 Antibody - SIM2 antibody Western blot of Fetal Kidney lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SIM2 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Xenopus, Chicken, Zebrafish, Rabbit, Mouse, Dog, Guinea pig, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
SIM2 Antibody - SIM2 antibody Western blot of Fetal Kidney lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SIM2 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Rabbit, Mouse, Dog, Guinea pig, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
SIM2 Antibody - SIM2 antibody Western blot of Fetal Kidney lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SIM2 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Rabbit, Mouse, Dog, Guinea pig, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
SIM2 Antibody - Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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SIM2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Select
SIM2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
SIM2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
SIM2 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
Select
SIM2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$341
Select
SIM2 Mouse anti-Human Monoclonal (aa426-526) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$614
SIM2 Antibody - Detection limit for recombinant GST tagged SIM2 is approximately 0.03 ng/ml as a capture antibody.
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SIM2 Mouse anti-Human Monoclonal (3E6) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
SIM2 Antibody - SIM2 antibody (0.5 ug/ml) staining of fetal Mouse kidney lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Select
SIM2 Goat anti-Human Polyclonal (aa428-437) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
Select
SIM2 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
SIM2 Antibody - Western blot analysis of extracts of various cell lines, using SIM2 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 5s.
Select
SIM2 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
SIM2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
63.3 kDa
100 µg/$710
SIM2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
63.3 kDa
20 µg/$215
Viewing 1-16 of 16 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).