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Anti-SIGLEC7 / CD328 Antibody (clone S7.7, FITC) LS-C187562

Ordering

Wt. Vol. Conc. Price
100 µg - 0.1 mg/ml $335
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular SIGLEC7 / CD328 Antibodies

Anti-SIGLEC7 / CD328 Antibody (clone 5-386, FITC) LS-C58113
Mouse Monoclonal [clone 5-386] (IgG1) to Human SIGLEC7 / CD328
Human
IHC - Frozen, Flow Cytometry
FITC Conjugated
Anti-SIGLEC7 / CD328 Antibody (PE) LS-C132108
Mouse Monoclonal (IgG1) to Human SIGLEC7 / CD328
Human
Flow Cytometry
PE Conjugated
Anti-SIGLEC7 / CD328 Antibody (aa1-30) IHC-plus™ LS-B6906
Rabbit Polyclonal to Human SIGLEC7 / CD328
Human, Mouse
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone S7.7] (IgG1) to Human SIGLEC7 / CD328
Human, Monkey, Rhesus monkey
Western blot, Immunoprecipitation, Flow Cytometry, ELISA (applications tested for the base form of this product only)
FITC Conjugated

Details

Human SIGLEC7 / CD328
Mouse
Human, Monkey, Rhesus monkey (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [S7.7]
Fluorescein. Also available Unconjugated.
Protein G purified
Unmodified

Applications

  • Western blot
  • Immunoprecipitation
  • Flow Cytometry
  • ELISA
  • (applications tested for the base form of this product only)

Specificity and Use

SIGLEC7 / CD328 antibody was raised against siglec-7 3T3 transfected cells.
Recognizes human Sialic acid-binding Ig-like lectin 7, otherwise known as CD328, a putative adhesion molecule and member of the Ig superfamily, predominantly expressed by both resting and activated natural killer (NK) cells, and also at lower levels by monocytes, granulocytes, monocyte-derived macrophages and dendritic cells, and a small population of CD8+ memory T cells. Classified as a CD33-related Siglec, Siglec-7 preferentially binds to glycoconjugates containing alpha-2,3- or alpha-2,6-linked sialic acid, and acts as a novel inhibitory receptor for NK cells, mediating the inhibition of NK cell cytotoxicity, and implicated in the regulation of NK cell and T cell activation, and hematopoiesis. Clone S7.7 is a blocking antibody see for details, and has been shown to recognize Siglec-7 in Rhesus monkey see for details.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Packaging

PBS, 0.09% sodium azide, 1% BSA
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About SIGLEC7 / CD328

Q9Y286 NM_014385 NP_055200.1

SIGLEC7 Antibody, AIRM-1 Antibody, AIRM1 Antibody, CD328 antigen Antibody, CDw328 Antibody, CD328 Antibody, D-siglec Antibody, QA79 Antibody, SIGLEC-7 Antibody, QA79 membrane protein Antibody

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Flow Cytometry

Flow Cytometry
Human peripheral blood lymphocytes stained with Mouse anti-Human Siglec-7: FITC This image was taken for the unconjugated form of this product. Other forms have not been tested.
 

Requested From: United States
Date Requested: 12/4/2016

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