Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 1116-NS-19-9] (IgG1) to Human Sialylated Lewis a / CA 19-9
IHC - Paraffin, IHC - Frozen
Human Sialylated Lewis a / CA 19-9
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [1116-NS-19-9]
IHC - Paraffin (1:10 - 1:40)
IHC - Frozen (1:10 - 1:40)
Specificity and Use
Is a carbohydrate antigenic determinant identified as a sialylated lacto-N-fucopentose II, an oligosaccharide biochemically related to the Lewis A blood group antigen. In malignant tissues positive staining of tumor cells is observed in most adenocarcinomas of the pancreas and stomach, and in a large proportion of colon and gall bladder tumors. The antigen is also expressed in approximately half of primary and metastatic ovarian tumors. In normal tissues positive staining is also observed in columnar epithelium of the pancreas stomach, liver, gall bladder and in bronchial glands of the lung.
Immunohistochemistry: This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. NB. A minimum incubation time of 1 hour is recommended. Histology Positive Control Tissue: Adenocarcinoma of colon.