SIAH2

siah E3 ubiquitin protein ligase 2

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not. Promotes monoubiquitination of SNCA.

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Antibodies (33)

Proteins (5)

ELISA Kits (3)

Type

Custom (2)

Over-Expression Lysate (2)

Primary (33)

Recombinant (3)

Sandwich (1)

Target

SIAH2 (41)

Reactivity

Human (32)

Mouse (14)

Rat (11)

Bat (3)

Bovine (3)

Chicken (3)

Chimpanzee (6)

Dog (3)

Drosophila (1)

Gibbon (6)

Guinea pig (3)

Horse (3)

Monkey (6)

Pig (4)

Rabbit (3)

Xenopus (3)

Zebrafish (4)

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Application

IHC (14)

IHC-Fr (1)

IHC-P (7)

WB (25)

Flo (8)

ELISA (14)

ICC (2)

IF (5)

Peptide-ELISA (2)

Host

rabbit (31)

mouse (2)

Product Group

IHCPlus (2)

PathPlus Cancer (2)

Isotype

IgG (16)

IgG1 (1)

IgG2b,k (1)

Clonality

monoclonal mc (2)

polyclonal pc (31)

Clone

1F5 (1)

24E6H3 (1)

Format

96-Well Strip Plate (3)

APC Conjugated (1)

Azide-free (1)

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FITC Conjugated (4)

HRP Conjugated (4)

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Preservative Free (1)

Unconjugated (19)

Epitope

aa216-244 (7)

N-Terminus (6)

aa215-264 (4)

210-290 aa, C-terminal (1)

C-Terminus (1)

Glu266 (1)

aa241-290 (1)

Publications

No (41)

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Plasma (2)

Serum (2)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

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Human (4)

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293T Cells (1)

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Wheat Germ Extract (2)

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Purified (1)

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IHC-plus™ SIAH2 Antibody (C-Terminus) LS-B13708

(4.0) Rating

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Zebrafish, Rat, Mouse, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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SIAH2 Antibody (N-Terminus) LS-C112149

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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PathPlus™ SIAH2 Antibody (aa216-244) LS-B16461

Cancer

(5.0) Rating

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (aa216-244) Antibody

Reactivity:

Human

Applications:

Flo, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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SIAH2 Antibody (N-Terminus, clone 24E6H3) LS-C141889

Antibody:

SIAH2 Mouse anti-Drosophila Monoclonal (N-Terminus) (24E6H3) Antibody

Reactivity:

Drosophila, Pig, Human

Applications:

Flo, ICC, IF, IHC, IHC-Fr, IHC-P

Format:

Unconjugated

Price:

0.5 ml/$386

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SIAH2 Antibody LS-C801522

Antibody:

SIAH2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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SIAH2 Antibody LS-C681330

Antibody:

SIAH2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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SIAH2 Antibody (FITC) LS-C681333

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• FITC

• Unconjugated
• FITC

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SIAH2 Antibody (aa216-244) LS-C325107

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (aa216-244) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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SIAH2 Antibody (aa216-244, Biotin) LS-C217493

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (aa216-244) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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SIAH2 Antibody (aa216-244, FITC) LS-C217494

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (aa216-244) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

SIAH2 Antibody (aa216-244, APC) LS-C217492

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (aa216-244) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

SIAH2 Antibody (aa216-244, PE) LS-C217496

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (aa216-244) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

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SIAH2 Antibody (aa216-244, Azide-free, HRP) LS-C217495

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (aa216-244) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

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IHC-plus™ SIAH2 Antibody LS-A11130

Fast Shipping

(4.0) Rating

Antibody:

SIAH2 Rabbit anti-Human Polyclonal Antibody

Applications:

IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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SIAH2 Antibody LS-C417269

Antibody:

SIAH2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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PathPlus™ SIAH2 Antibody LS-A11127

Cancer

Fast Shipping

(5.0) Rating

Antibody:

SIAH2 Rabbit anti-Human Polyclonal Antibody

Applications:

IHC-P

Format:

Unconjugated

Price:

50 µg/$460

Select

SIAH2 Antibody (210-290 aa, C-terminal) LS-C386061

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (210-290 aa, C-terminal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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SIAH2 Antibody (Glu266) LS-C176983

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (Glu266) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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SIAH2 Antibody (N-Terminus) LS-C144691

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$440; 200 µl/$468

Select

SIAH2 Antibody LS-C753213

Antibody:

SIAH2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$341

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SIAH2 Antibody LS-C824784

Antibody:

SIAH2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

SIAH2 Antibody (aa241-290) LS-C120495

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (aa241-290) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

SIAH2 Antibody (clone 1F5) LS-C198195

Antibody:

SIAH2 Mouse anti-Human Monoclonal (1F5) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µg/$423

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SIAH2 Antibody (aa215-264) LS-C109768

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (aa215-264) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

SIAH2 Antibody (Preservative Free) LS-C815429

Antibody:

SIAH2 Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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