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SHSF1 / SHFM1

26S proteasome complex subunit SEM1

Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (PubMed:15117943). Component <br>of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and <br>either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent <br>ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 <br>participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear <br>periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus <br>transcription-associated genomic instability. R-loop accumulation increases in DSS1-depleted cells.

Gene Name: 26S proteasome complex subunit SEM1
Synonyms: SEM1, DSS1, SHSF1, SHFD1, Shfdg1, SHFM1
Target Sequences: NM_006304 NP_006295.1 P60896

Publications (1)

1
Small and big Hodgkin-Reed-Sternberg cells of Hodgkin lymphoma cell lines L-428 and L-1236 lack consistent differences in gene expression profiles and are capable to reconstitute each other. Rengstl B, Kim S, Döring C, Weiser C, Bein J, Bankov K, Herling M, Newrzela S, Hansmann ML, Hartmann S. PloS one. 2017 12:e0177378. (ICC, WB, ELISA; Human) [Full Text Article] [PubMed:28505189]

☰ Filters
Antibodies (13)
Proteins (4)
Over-Expression Lysate (2)
Primary (13)
Recombinant (2)
SHSF1 / SHFM1 (17)
Human (13)
Mouse (2)
Rat (2)
Bat (1)
Bovine (1)
Chicken (1)
Dog (1)
Horse (1)
Monkey (1)
Pig (1)
Rabbit (1)
Xenopus (1)
Zebrafish (1)
IHC (7)
WB (2)
ELISA (11)
ICC (1)
IF (1)
Peptide-ELISA (2)
rabbit (12)
goat (1)
IgG (12)
polyclonal pc (13)
APC Conjugated (1)
Azide-free (2)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (5)
N-Terminus (6)
aa21-40 (1)
aa57-70 (1)
No (17)
GST (1)
His (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (2)
SHSF1 / SHFM1 Antibody - 1:100 staining rat lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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SHSF1 / SHFM1 Rabbit anti-Human Polyclonal (aa21-40) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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SHSF1 / SHFM1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$351
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SHSF1 / SHFM1 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Human
ELISA, IHC
Biotin Conjugated
200 µl/$952
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SHSF1 / SHFM1 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Human
ELISA, IHC
FITC Conjugated
200 µl/$952
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SHSF1 / SHFM1 Rabbit anti-Human Polyclonal (N-Terminus) (Azide-free) Antibody
Human
ELISA, IHC
Unconjugated, Azide-free
200 µl/$734
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SHSF1 / SHFM1 Rabbit anti-Human Polyclonal (N-Terminus) (APC) Antibody
Human
ELISA, IHC
APC Conjugated
200 µl/$952
Select
SHSF1 / SHFM1 Rabbit anti-Human Polyclonal (N-Terminus) (PE) Antibody
Human
ELISA, IHC
PE Conjugated
200 µl/$952
Select
SHSF1 / SHFM1 Rabbit anti-Human Polyclonal (N-Terminus) (Azide-free) (HRP) Antibody
Human
ELISA, IHC
HRP Conjugated, Azide-free
200 µl/$952
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SHSF1 / SHFM1 Goat anti-Human Polyclonal (aa57-70) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Rabbit, Mouse, Dog, Bovine, Bat, Rat, Human, Monkey
ICC, Peptide-ELISA
Unconjugated
100 µg/$503
SHSF1 / SHFM1 Antibody - Immunohistochemistry of paraffin-embedded human lung tissue using SEM1 Antibody at dilution of 1:100
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SHSF1 / SHFM1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
Select
SHSF1 / SHFM1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
SHSF1 / SHFM1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
SHSF1 / SHFM1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
SHSF1 / SHFM1 Protein - 12.5% SDS-PAGE of human SHFM1 stained with Coomassie Blue
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Wheat Germ Extract
GST
34.7 kDa
10 µg/$479; 25 µg/$670
SHSF1 / SHFM1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
8.1 kDa
100 µg/$494
SHSF1 / SHFM1 Protein
Select
E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
SHSF1 / SHFM1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
8.1 kDa
20 µg/$150
Viewing 1-17 of 17 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).