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SH3RF1 / POSH
SH3 domain containing ring finger 1
Acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9) (By similarity). May be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.
| Gene Name: | SH3 domain containing ring finger 1 |
| Synonyms: | SH3RF1, KIAA1494, Plenty of SH3s, RING finger protein 142, SH3 multiple domains 2, SH3 multiple domains protein 2, SH3MD2, Plenty of SH3 domains, POSH, Protein POSH, RNF142 |
| Target Sequences: | AB040927 NP_065921.2 Q7Z6J0 |
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